PDB entry 4f3i

View 4f3i on RCSB PDB site
Description: Crystal structure of the first bromodomain of human BRD4 in complex with MS417 inhibitor
Class: signaling protein/inhibitor
Keywords: protein-inhibitor complex, acetyl-lysine binding, nucleus, SIGNALING PROTEIN-INHIBITOR complex
Deposited on 2012-05-09, released 2012-09-12
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-09-12, with a file datestamp of 2012-09-07.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: 0.139
AEROSPACI score: 0.75 (click here for full SPACI score report)

Chains and heterogens:

• Chain 'A':
  Compound: Bromodomain-containing protein 4
  Species: Homo sapiens [TaxId:9606]
  Gene: BRD4, HUNK1
  Database cross-references and differences (RAF-indexed):
  • Uniprot O60885 (2-126)
    • expression tag (0-1)
  Domains in SCOPe 2.03: d4f3ia_
• Heterogens: EDO, 0S6, HOH

PDB Chain Sequences:

• Chain 'A':
  Sequence; same for both SEQRES and ATOM records: (download)
  

  >4f3iA (A:)
  smnppppetsnpnkpkrqtnqlqyllrvvlktlwkhqfawpfqqpvdavklnlpdyykii
  ktpmdmgtikkrlennyywnaqeciqdfntmftncyiynkpgddivlmaealeklflqki
  nelptee