PDB entry 4f2w

View 4f2w on RCSB PDB site
Description: Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with methyl-thio-DADMe-Immucillin-A
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: L-methionine biosynthetic process from S-adenosylmethionine, L-methionine salvage from methylthioadenosine, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, adenosylhomocysteine nucleosidase activity, methylthioadenosine nucleosidase activity, acting on glycosyl bonds, HYDROLASE-HYDROLASE inhibitor complex
Deposited on 2012-05-08, released 2013-05-01
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-06-19, with a file datestamp of 2013-06-14.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.179
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Species: Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50 [TaxId:904139]
    Gene: EMBL EFZ04802.1, mtnN, pfs, SCA50_0219, SCH_0207
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4f2wa_
  • Chain 'B':
    Compound: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Species: Salmonella enterica subsp. enterica serovar Choleraesuis str. SCSA50 [TaxId:904139]
    Gene: EMBL EFZ04802.1, mtnN, pfs, SCA50_0219, SCH_0207
    Database cross-references and differences (RAF-indexed):
    • Uniprot E8NLP5 (16-End)
      • expression tag (9-15)
    Domains in SCOPe 2.08: d4f2wb1, d4f2wb2
  • Heterogens: TDI, EDO, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4f2wA (A:)
    mhhhhhhgglvprgshmkigiigameeevtllrdkidnrqtitlggceiytgqlngteva
    llksgigkvaaalgatlllehckpdviintgsagglastlkvgdivvsdetryhdadvta
    fgyeygqlpgcpagfkaddkliaaaescirelnlnavrglivsgdafingsvglakirhn
    fpdavavemeataiahvchnfnvpfvvvraisdvadqqshlsfdeflavaakqstlmvet
    lvqklahg
    

    Sequence, based on observed residues (ATOM records): (download)
    >4f2wA (A:)
    mkigiigameeevtllrdkidnrqtitlggceiytgqlngtevallksgigkvaaalgat
    lllehckpdviintgsagglastlkvgdivvsdetryhdadvtafgyeygqlpgcpagfk
    addkliaaaescirelnlnavrglivsgdafingsvglakirhnfpdavavemeataiah
    vchnfnvpfvvvraisdvadqqshlsfdeflavaakqstlmvetlvqklah
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4f2wB (B:)
    mhhhhhhgglvprgshmkigiigameeevtllrdkidnrqtitlggceiytgqlngteva
    llksgigkvaaalgatlllehckpdviintgsagglastlkvgdivvsdetryhdadvta
    fgyeygqlpgcpagfkaddkliaaaescirelnlnavrglivsgdafingsvglakirhn
    fpdavavemeataiahvchnfnvpfvvvraisdvadqqshlsfdeflavaakqstlmvet
    lvqklahg
    

    Sequence, based on observed residues (ATOM records): (download)
    >4f2wB (B:)
    lvprgshmkigiigameeevtllrdkidnrqtitlggceiytgqlngtevallksgigkv
    aaalgatlllehckpdviintgsagglastlkvgdivvsdetryhdadvtafgyeygqlp
    gcpagfkaddkliaaaescirelnlnavrglivsgdafingsvglakirhnfpdavavem
    eataiahvchnfnvpfvvvraisdvadqqshlsfdeflavaakqstlmvetlvqkla