PDB entry 4f2p

View 4f2p on RCSB PDB site
Description: Crystal structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Salmonella enterica with diEtglycol-thio-DADMe-Immucillin-A
Class: HYDROLASE/HYDROLASE inhibitor
Keywords: L-methionine biosynthetic process from S-adenosylmethionine, L-methionine salvage from methylthioadenosine, 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase, adenosylhomocysteine nucleosidase activity, methylthioadenosine nucleosidase activity, acting on glycosyl bonds, HYDROLASE-HYDROLASE inhibitor complex
Deposited on 2012-05-08, released 2013-05-01
The last revision prior to the SCOPe 2.04 freeze date was dated 2013-06-19, with a file datestamp of 2013-06-14.
Experiment type: XRAY
Resolution: 1.64 Å
R-factor: 0.165
AEROSPACI score: 0.59 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Species: Salmonella enterica subsp. enterica serovar Choleraesuis [TaxId:904139]
    Gene: EMBL EFZ04802.1, mtnN, pfs, SCA50_0219, SCH_0207
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4f2pa_
  • Chain 'B':
    Compound: 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase
    Species: Salmonella enterica subsp. enterica serovar Choleraesuis [TaxId:904139]
    Gene: EMBL EFZ04802.1, mtnN, pfs, SCA50_0219, SCH_0207
    Database cross-references and differences (RAF-indexed):
    • Uniprot E8NLP5 (16-247)
      • expression tag (9-15)
    Domains in SCOPe 2.04: d4f2pb_
  • Heterogens: 2EL, ACT, GOL, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4f2pA (A:)
mhhhhhhgglvprgshmkigiigameeevtllrdkidnrqtitlggceiytgqlngteva
llksgigkvaaalgatlllehckpdviintgsagglastlkvgdivvsdetryhdadvta
fgyeygqlpgcpagfkaddkliaaaescirelnlnavrglivsgdafingsvglakirhn
fpdavavemeataiahvchnfnvpfvvvraisdvadqqshlsfdeflavaakqstlmvet
lvqklahg

    Sequence, based on observed residues (ATOM records): (download) 
    >4f2pA (A:)
mkigiigameeevtllrdkidnrqtitlggceiytgqlngtevallksgigkvaaalgat
lllehckpdviintgsagglastlkvgdivvsdetryhdadvtafgyeygqlpgcpagfk
addkliaaaescirelnlnavrglivsgdafingsvglakirhnfpdavavemeataiah
vchnfnvpfvvvraisdvadqqshlsfdeflavaakqstlmvetlvqklah

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4f2pB (B:)
mhhhhhhgglvprgshmkigiigameeevtllrdkidnrqtitlggceiytgqlngteva
llksgigkvaaalgatlllehckpdviintgsagglastlkvgdivvsdetryhdadvta
fgyeygqlpgcpagfkaddkliaaaescirelnlnavrglivsgdafingsvglakirhn
fpdavavemeataiahvchnfnvpfvvvraisdvadqqshlsfdeflavaakqstlmvet
lvqklahg

    Sequence, based on observed residues (ATOM records): (download) 
    >4f2pB (B:)
lvprgshmkigiigameeevtllrdkidnrqtitlggceiytgqlngtevallksgigkv
aaalgatlllehckpdviintgsagglastlkvgdivvsdetryhdadvtafgyeygqlp
gcpagfkaddkliaaaescirelnlnavrglivsgdafingsvglakirhnfpdavavem
eataiahvchnfnvpfvvvraisdvadqqshlsfdeflavaakqstlmvetlvqklahg