PDB entry 4ezm

View 4ezm on RCSB PDB site
Description: Crystal structure of the human IgE-Fc(epsilon)3-4 bound to its B cell receptor derCD23
Class: immune system
Keywords: Immunoglobulin fold Lectin, Antibody Receptor, IMMUNE SYSTEM
Deposited on 2012-05-03, released 2012-07-18
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-08-15, with a file datestamp of 2012-08-10.
Experiment type: XRAY
Resolution: 3.1 Å
R-factor: 0.265
AEROSPACI score: 0.17 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ig epsilon chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01854
      • engineered mutation (46)
      • engineered mutation (58)
    Domains in SCOPe 2.06: d4ezma1, d4ezma2
  • Chain 'B':
    Compound: ig epsilon chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01854
      • engineered mutation (46)
      • engineered mutation (58)
    Domains in SCOPe 2.06: d4ezmb1, d4ezmb2
  • Chain 'C':
    Compound: ig epsilon chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01854
      • engineered mutation (58)
    Domains in SCOPe 2.06: d4ezmc1, d4ezmc2
  • Chain 'D':
    Compound: ig epsilon chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01854
      • engineered mutation (46)
      • engineered mutation (58)
    Domains in SCOPe 2.06: d4ezmd1, d4ezmd2
  • Chain 'E':
    Compound: ig epsilon chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01854
      • engineered mutation (46)
      • engineered mutation (58)
    Domains in SCOPe 2.06: d4ezme1, d4ezme2
  • Chain 'F':
    Compound: ig epsilon chain c region
    Species: Homo sapiens [TaxId:9606]
    Gene: IGHE
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01854
      • engineered mutation (46)
      • engineered mutation (58)
    Domains in SCOPe 2.06: d4ezmf1, d4ezmf2
  • Chain 'G':
    Compound: Low affinity immunoglobulin epsilon Fc receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FCER2, CD23A, CLEC4J, FCE2, IGEBF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ezmg_
  • Chain 'H':
    Compound: Low affinity immunoglobulin epsilon Fc receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FCER2, CD23A, CLEC4J, FCE2, IGEBF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ezmh_
  • Chain 'I':
    Compound: Low affinity immunoglobulin epsilon Fc receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FCER2, CD23A, CLEC4J, FCE2, IGEBF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ezmi_
  • Chain 'J':
    Compound: Low affinity immunoglobulin epsilon Fc receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FCER2, CD23A, CLEC4J, FCE2, IGEBF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ezmj_
  • Chain 'K':
    Compound: Low affinity immunoglobulin epsilon Fc receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FCER2, CD23A, CLEC4J, FCE2, IGEBF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ezmk_
  • Chain 'L':
    Compound: Low affinity immunoglobulin epsilon Fc receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: FCER2, CD23A, CLEC4J, FCE2, IGEBF
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4ezml_
  • Heterogens: MAN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ezmA (A:)
adpcadsnprgvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqh
strkeekqrngtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraape
vyafatpewpgsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgff
vfsrlevtraeweqkdeficravheaaspsqtvqravsvnpgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmA (A:)
gvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqhstrkeekqrn
gtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraapevyafatpewp
gsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtra
eweqkdeficravheaaspsqtvqravsvnp

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ezmB (B:)
adpcadsnprgvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqh
strkeekqrngtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraape
vyafatpewpgsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgff
vfsrlevtraeweqkdeficravheaaspsqtvqravsvnpgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmB (B:)
vsaylsrpspfdlfirksptitclvvdpskgtvqltwsrasgkpvqhstrkeekqrngtl
tvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraapevyafatpewpgsr
dkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtraewe
qkdeficravheaaspsqtvqravsvnp

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ezmC (C:)
adpcadsnprgvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqh
strkeekqrngtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraape
vyafatpewpgsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgff
vfsrlevtraeweqkdeficravheaaspsqtvqravsvnpgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmC (C:)
vsaylsrpspfdlfirksptitclvvdlapsltwsrasgkpvqhstrkeekqrngtltvt
stlpvgtrdwiegetyqcrvlmrsttktsgpraapevyafatpewpgsrdkrtlacliqn
fmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtraeweqkdeficravh
eaaspsqtvqravsvnp

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ezmD (D:)
adpcadsnprgvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqh
strkeekqrngtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraape
vyafatpewpgsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgff
vfsrlevtraeweqkdeficravheaaspsqtvqravsvnpgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmD (D:)
gvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqhstrkeekqrn
gtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraapevyafatpewp
gsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtra
eweqkdeficravheaaspsqtvqrav

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4ezmE (E:)
adpcadsnprgvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqh
strkeekqrngtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraape
vyafatpewpgsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgff
vfsrlevtraeweqkdeficravheaaspsqtvqravsvnpgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmE (E:)
gvsaylsrpspfdlfirksptitclvvdlapsqltwsrasgkpvqhstrkeekqrngtlt
vtstlpvgtrdwiegetyqcphlprarsttktsgpraapevyafatpewpgsrdkrtlac
liqnfmpedisvqwnevqlpdarhsttqprktkgsgffvfsrlevtraewdeficravhe
aaspsqtvqra

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4ezmF (F:)
adpcadsnprgvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqh
strkeekqrngtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraape
vyafatpewpgsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgff
vfsrlevtraeweqkdeficravheaaspsqtvqravsvnpgk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmF (F:)
gvsaylsrpspfdlfirksptitclvvdlapskgtvqltwsrasgkpvqhstrkeekqrn
gtltvtstlpvgtrdwiegetyqcrvthphlpralmrsttktsgpraapevyafatpewp
gsrdkrtlacliqnfmpedisvqwlhnevqlpdarhsttqprktkgsgffvfsrlevtra
eweqkdeficravheaaspsqtvqravs

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4ezmG (G:)
sgfvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhas
htgswiglrnldlkgefiwvdgshvdysnwapgeptsrsqgedcvmmrgsgrwndafcdr
klgawvcdrlatctppasegsae

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmG (G:)
fvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhasht
gswiglrnldlkgefiwvdgshvdysnwapgeptsrsqdcvmmrgsgrwndafcdrklga
wvcdrlatctppa

  • Chain 'H':
    Sequence, based on SEQRES records: (download) 
    >4ezmH (H:)
sgfvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhas
htgswiglrnldlkgefiwvdgshvdysnwapgeptsrsqgedcvmmrgsgrwndafcdr
klgawvcdrlatctppasegsae

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmH (H:)
fvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhasht
gswiglrnldlkgefiwvdgshvdysnwapgeptsrsqdcvmmrgsgrwndafcdrklga
wvcdrlatctppa

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4ezmI (I:)
sgfvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhas
htgswiglrnldlkgefiwvdgshvdysnwapgeptsrsqgedcvmmrgsgrwndafcdr
klgawvcdrlatctppasegsae

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmI (I:)
fvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhasht
gswiglrnldlkgefiwvdgshvdysnwapgeptsrsqdcvmmrgsgrwndafcdrklga
wvcdrlatctppa

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >4ezmJ (J:)
sgfvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhas
htgswiglrnldlkgefiwvdgshvdysnwapgeptsrsqgedcvmmrgsgrwndafcdr
klgawvcdrlatctppasegsae

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmJ (J:)
fvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhasht
gswiglrnldlkgefiwvdgshvdysnwapgeptsrsqdcvmmrgsgrwndafcdrklga
wvcdrlatctppa

  • Chain 'K':
    Sequence, based on SEQRES records: (download) 
    >4ezmK (K:)
sgfvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhas
htgswiglrnldlkgefiwvdgshvdysnwapgeptsrsqgedcvmmrgsgrwndafcdr
klgawvcdrlatctppasegsae

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmK (K:)
gfvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhash
tgswiglrnldlkgefiwvdgshvdysnwapgeptsrsqdcvmmrgsgrwndafcdrklg
awvcdrlatctppa

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4ezmL (L:)
sgfvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhas
htgswiglrnldlkgefiwvdgshvdysnwapgeptsrsqgedcvmmrgsgrwndafcdr
klgawvcdrlatctppasegsae

    Sequence, based on observed residues (ATOM records): (download) 
    >4ezmL (L:)
fvcntcpekwinfqrkcyyfgkgtkqwvharyacddmegqlvsihspeeqdfltkhasht
gswiglrnldlkgefiwvdgshvdysnwapgeptsrsqgedcvmmrgsgrwndafcdrkl
gawvcdrlatctpp