PDB entry 4ey5

View 4ey5 on RCSB PDB site
Description: Crystal Structure of Recombinant Human Acetylcholinesterase in Complex with (-)-huperzine A
Class: hydrolase/hydrolase inhibitor
Keywords: acetylcholinesterase, hydrolase, huperzine A, inhibitor, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-05-01, released 2012-10-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: N/A
AEROSPACI score: 0.33 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ey5a_
  • Chain 'B':
    Compound: acetylcholinesterase
    Species: Homo sapiens [TaxId:9606]
    Gene: ACHE
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4ey5b_
  • Heterogens: HUP, DMS, EDO, NAG, NO3, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ey5A (A:)
gredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvd
attfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygg
gfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalq
wvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgm
gearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvp
vvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraefla
gvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaq
garvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywa
nfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpklls
at

    Sequence, based on observed residues (ATOM records): (download) 
    >4ey5A (A:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcpndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdgdfls
dtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrvgvpq
vsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarvyayv
fehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfartgdp
neprdpqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ey5B (B:)
gredaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvd
attfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygg
gfysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalq
wvqenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgm
gearrratqlahlvgcppggtggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvp
vvdgdflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraefla
gvrvgvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaq
garvyayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywa
nfartgdpneprdpkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpklls
at

    Sequence, based on observed residues (ATOM records): (download) 
    >4ey5B (B:)
edaellvtvrggrlrgirlktpggpvsaflgipfaeppmgprrflppepkqpwsgvvdat
tfqsvcyqyvdtlypgfegtemwnpnrelsedclylnvwtpyprptsptpvlvwiygggf
ysgassldvydgrflvqaertvlvsmnyrvgafgflalpgsreapgnvglldqrlalqwv
qenvaafggdptsvtlfgesagaasvgmhllsppsrglfhravlqsgapngpwatvgmge
arrratqlahlvgcpptggndtelvaclrtrpaqvlvnhewhvlpqesvfrfsfvpvvdg
dflsdtpealinagdfhglqvlvgvvkdegsyflvygapgfskdneslisraeflagvrv
gvpqvsdlaaeavvlhytdwlhpedparlrealsdvvgdhnvvcpvaqlagrlaaqgarv
yayvfehrastlswplwmgvphgyeiefifgipldpsrnytaeekifaqrlmrywanfar
tgdpneppkapqwppytagaqqyvsldlrplevrrglraqacafwnrflpkllsa