PDB entry 4evy

View 4evy on RCSB PDB site
Description: Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ig from Acinetobacter haemolyticus in complex with tobramycin
Class: transferase/antibiotic
Keywords: Center for Structural Genomics of Infectious Diseases (CSGID), NIAID, National Institute of Allergy and Infectious Diseases, GNAT superfamily, GCN5-related N-acetyltransferase superfamily, N-acetyltransferase fold, antibiotic resistance, acetyl coenzyme A, intracellular, TRANSFERASE-ANTIBIOTIC complex
Deposited on 2012-04-26, released 2012-05-09
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-02-22, with a file datestamp of 2017-02-17.
Experiment type: XRAY
Resolution: 1.77 Å
R-factor: N/A
AEROSPACI score: 0.38 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aminoglycoside N(6')-acetyltransferase type 1
    Species: Acinetobacter haemolyticus [TaxId:29430]
    Gene: aac(6')-Ig
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q44057 (21-165)
      • expression tag (19-20)
    Domains in SCOPe 2.08: d4evya1, d4evya2
  • Chain 'B':
    Compound: Aminoglycoside N(6')-acetyltransferase type 1
    Species: Acinetobacter haemolyticus [TaxId:29430]
    Gene: aac(6')-Ig
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4evyb_
  • Heterogens: TOY, K, CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4evyA (A:)
mgsshhhhhhssgrenlyfqgmnikpaseaslkdwlelrnklwsdseashlqemhqllae
kyalqllaysdhqaiamleasirfeyvngtetspvgflegiyvlpahrrsgvatmlirqa
evwakqfsctefasdaaldnvishamhrslgfqetekvvyfskkid

    Sequence, based on observed residues (ATOM records): (download) 
    >4evyA (A:)
qgmnikpaseaslkdwlelrnklwsdseashlqemhqllaekyalqllaysdhqaiamle
asirfeyvngtetspvgflegiyvlpahrrsgvatmlirqaevwakqfsctefasdaald
nvishamhrslgfqetekvvyfskkid

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4evyB (B:)
mgsshhhhhhssgrenlyfqgmnikpaseaslkdwlelrnklwsdseashlqemhqllae
kyalqllaysdhqaiamleasirfeyvngtetspvgflegiyvlpahrrsgvatmlirqa
evwakqfsctefasdaaldnvishamhrslgfqetekvvyfskkid

    Sequence, based on observed residues (ATOM records): (download) 
    >4evyB (B:)
mnikpaseaslkdwlelrnklwsdseashlqemhqllaekyalqllaysdhqaiamleas
irfeyvngtetspvgflegiyvlpahrrsgvatmlirqaevwakqfsctefasdaaldnv
ishamhrslgfqetekvvyfskkid