PDB entry 4epy

View 4epy on RCSB PDB site
Description: Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-mediated Activation
Class: hydrolase
Keywords: Small molecule complex crystal structure, KRas, p21, GTP-binding protein, oncogenes, binder, HYDROLASE, Inhibitor of Sos-mediated activation
Deposited on 2012-04-17, released 2012-05-23
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-07-25, with a file datestamp of 2012-07-20.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.163
AEROSPACI score: 0.54 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: GTPase KRas
    Species: Homo sapiens [TaxId:9606]
    Gene: KRAS, KRAS2, RASK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01116 (1-169)
      • expression tag (0)
      • engineered mutation (12)
      • engineered mutation (118)
    Domains in SCOPe 2.08: d4epya1, d4epya2
  • Heterogens: GDP, MG, 0QY, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4epyA (A:)
gmteyklvvvgavgvgksaltiqliqnhfvdeydptiedsyrkqvvidgetclldildta
gqeeysamrdqymrtgegflcvfainntksfedihhyreqikrvkdsedvpmvlvgnksd
lpsrtvdtkqaqdlarsygipfietsaktrqgvddafytlvreirkhkek