PDB entry 4eok
View 4eok on RCSB PDB site
Description: Thr 160 phosphorylated CDK2 H84S, Q85M, K89D - human cyclin A3 complex with the inhibitor NU6102
Class: Transferase/Transferase Inhibitor
Keywords: protein kinase, cell cycle, PHOSPHORYLATION, Transferase-Transferase Inhibitor complex
Deposited on
2012-04-14, released
2013-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated
2013-02-06, with a file datestamp of
2013-02-01.
Experiment type: XRAY
Resolution: 2.57 Å
R-factor: 0.225
AEROSPACI score: 0.29
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: cyclin-dependent kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2, CDKN2
Database cross-references and differences (RAF-indexed):
- Uniprot P24941 (3-299)
- expression tag (2)
- engineered mutation (86-87)
- engineered mutation (91)
Domains in SCOPe 2.08: d4eoka1, d4eoka2 - Chain 'B':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4eokb1, d4eokb2 - Chain 'C':
Compound: cyclin-dependent kinase 2
Species: Homo sapiens [TaxId:9606]
Gene: CDK2, CDKN2
Database cross-references and differences (RAF-indexed):
- Uniprot P24941 (3-299)
- expression tag (0-2)
- engineered mutation (86-87)
- engineered mutation (91)
Domains in SCOPe 2.08: d4eokc1, d4eokc2 - Chain 'D':
Compound: Cyclin-A2
Species: Homo sapiens [TaxId:9606]
Gene: CCNA2, CCN1, CCNA
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4eokd1, d4eokd2 - Heterogens: 4SP, SGM, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4eokA (A:)
lgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllke
lnhpnivklldvihtenklylvfeflsmdlkdfmdasaltgiplpliksylfqllqglaf
chshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgc
kyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdyk
psfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr
Sequence, based on observed residues (ATOM records): (download)
>4eokA (A:)
smenfqkvekigegtygvvykarnkltgevvalkkirlegvpstaireisllkelnhpni
vklldvihtenklylvfeflsmdlkdfmdasaltgiplpliksylfqllqglafchshrv
lhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgckyysta
vdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdykpsfpkw
arqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4eokB (B:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl
- Chain 'C':
Sequence; same for both SEQRES and ATOM records: (download)
>4eokC (C:)
lgsmenfqkvekigegtygvvykarnkltgevvalkkirldtetegvpstaireisllke
lnhpnivklldvihtenklylvfeflsmdlkdfmdasaltgiplpliksylfqllqglaf
chshrvlhrdlkpqnllintegaikladfglarafgvpvrtythevvtlwyrapeillgc
kyystavdiwslgcifaemvtrralfpgdseidqlfrifrtlgtpdevvwpgvtsmpdyk
psfpkwarqdfskvvppldedgrsllsqmlhydpnkrisakaalahpffqdvtkpvphlr
- Chain 'D':
Sequence, based on SEQRES records: (download)
>4eokD (D:)
vpdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhl
avnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrm
ehlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsv
iagaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekyk
nskyhgvsllnppetlnl
Sequence, based on observed residues (ATOM records): (download)
>4eokD (D:)
pdyhedihtylremevkckpkvgymkkqpditnsmrailvdwlvevgeeyklqnetlhla
vnyidrflssmsvlrgklqlvgtaamllaskfeeiyppevaefvyitddtytkkqvlrme
hlvlkvltfdlaaptvnqfltqyflhqqpanckveslamflgelslidadpylkylpsvi
agaafhlalytvtgqswpeslirktgytleslkpclmdlhqtylkapqhaqqsirekykn
skyhgvsllnppetln