PDB entry 4ekx

View 4ekx on RCSB PDB site
Description: Crystal Structure of YLDV 14L IL-18 Binding Protein in Complex with Human IL-18
Class: CYTOKINE/Viral protein
Keywords: Binding Protein, beta trefoil, Immunoglobulin fold, YLDV, Yaba, yatapoxvirus, 14L, Cytokine Signaling, CYTOKINE-Viral protein complex
Deposited on 2012-04-10, released 2012-09-26
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14L protein
    Species: Yaba-like disease virus [TaxId:132475]
    Gene: 14L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9DHU8
      • engineered mutation (111)
  • Chain 'B':
    Compound: Interleukin-18
    Species: Homo sapiens [TaxId:9606]
    Gene: IGIF, IL-18, IL18, IL1F4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14116 (0-End)
      • engineered mutation (66-68)
      • engineered mutation (70)
      • engineered mutation (75)
      • engineered mutation (126)
    Domains in SCOPe 2.08: d4ekxb_
  • Chain 'C':
    Compound: 14L protein
    Species: Yaba-like disease virus [TaxId:132475]
    Gene: 14L
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9DHU8
      • engineered mutation (111)
  • Chain 'D':
    Compound: Interleukin-18
    Species: Homo sapiens [TaxId:9606]
    Gene: IGIF, IL-18, IL18, IL1F4
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14116 (0-End)
      • engineered mutation (37)
      • engineered mutation (66-70)
      • engineered mutation (75)
      • engineered mutation (126)
    Domains in SCOPe 2.08: d4ekxd_
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    No sequence available.

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ekxB (B:)
yfgklesklsvirnlndqvlfidqgnrplfedmtdsdsrdnaprtifiismykdsqprgm
avtisvasaaastlssenkiisfkemnppdnikdtksdiiffqrsvpghdnkmqfesssy
egyflasekerdlfklilkkedelgdrsimftvqned

    Sequence, based on observed residues (ATOM records): (download) 
    >4ekxB (B:)
yfgklesklsvirnlndqvlfidqgnrplfedmrtifiismykdsqprgmavtisvasaa
stlssenkiisfkemnppdnikdtksdiiffqrsvpghdnkmqfesssyegyflaseker
dlfklilkkelgdrsimftvqn

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ekxD (D:)
yfgklesklsvirnlndqvlfidqgnrplfedmtdsdsrdnaprtifiismykdsqprgm
avtisvasaaastlssenkiisfkemnppdnikdtksdiiffqrsvpghdnkmqfesssy
egyflasekerdlfklilkkedelgdrsimftvqned

    Sequence, based on observed residues (ATOM records): (download) 
    >4ekxD (D:)
yfgklesklsvirnlndqvlfidqgnrplfedmtdsdsrdnaprtifiismykdsqprgm
avtisvasaaastlssenkiisfkemnppdnikdtksdiiffqrsvpghdnkmqfesssy
egyflasekerdlfklilkkeelgdrsimftvqne