PDB entry 4ej1

View 4ej1 on RCSB PDB site
Description: Binding of Nb113 camelid antibody fragment with the binary DHFR:folate complex
Class: Oxidoreductase/Immune system
Keywords: FOLATE, Oxidoreductase-Immune system complex
Deposited on 2012-04-06, released 2013-04-24
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-10-30, with a file datestamp of 2013-10-25.
Experiment type: XRAY
Resolution: 1.75 Å
R-factor: 0.188
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:83333]
    Gene: folA, tmrA, b0048, JW0047
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4ej1a_
  • Chain 'B':
    Compound: dihydrofolate reductase
    Species: Escherichia coli [TaxId:83333]
    Gene: folA, tmrA, b0048, JW0047
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4ej1b_
  • Chain 'C':
    Compound: Nb113 camelid antibody fragment
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4EJ1
    Domains in SCOPe 2.07: d4ej1c1, d4ej1c2
  • Chain 'D':
    Compound: Nb113 camelid antibody fragment
    Species: Lama glama [TaxId:9844]
    Database cross-references and differences (RAF-indexed):
    • PDB 4EJ1
    Domains in SCOPe 2.07: d4ej1d1, d4ej1d2
  • Heterogens: FOL, PO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4ej1A (A:)
    misliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
    ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
    gdthfpdyepddwesvfsefhdadaqnshsycfeilerr
    

  • Chain 'B':
    Sequence; same for both SEQRES and ATOM records: (download)
    >4ej1B (B:)
    misliaalavdrvigmenampwnlpadlawfkrntlnkpvimgrhtwesigrplpgrkni
    ilssqpgtddrvtwvksvdeaiaacgdvpeimvigggrvyeqflpkaqklylthidaeve
    gdthfpdyepddwesvfsefhdadaqnshsycfeilerr
    

  • Chain 'C':
    Sequence, based on SEQRES records: (download)
    >4ej1C (C:)
    qvqlqesggglvqaggslrlsctasgrtfssyamgwfrqtpgkerefvaaitwggsttly
    adsvkgrftmsrdnakntvylqmnslkpedtavyycaadgsqyrstysfrdkpdygswgq
    gtqvtvsshhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ej1C (C:)
    qlqesggglvqaggslrlsctasgrtfssyamgwfrqtpgkerefvaaitwggsttlyad
    svkgrftmsrdnakntvylqmnslkpedtavyycaadgsqyrstysfrdkpdygswgqgt
    qvtvss
    

  • Chain 'D':
    Sequence, based on SEQRES records: (download)
    >4ej1D (D:)
    qvqlqesggglvqaggslrlsctasgrtfssyamgwfrqtpgkerefvaaitwggsttly
    adsvkgrftmsrdnakntvylqmnslkpedtavyycaadgsqyrstysfrdkpdygswgq
    gtqvtvsshhhhhh
    

    Sequence, based on observed residues (ATOM records): (download)
    >4ej1D (D:)
    qlqesggglvqaggslrlsctasgrtfssyamgwfrqtpgkerefvaaitwggsttlyad
    svkgrftmsrdnakntvylqmnslkpedtavyycaadgsqyrstysfrdkpdygswgqgt
    qvtvss