PDB entry 4ei4

View 4ei4 on RCSB PDB site
Description: JAK1 kinase (JH1 domain) in complex with compound 20
Class: transferase/transferase inhibitor
Keywords: protein kinase, phospho-transfer catalyst, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-04-04, released 2012-07-04
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-01-23, with a file datestamp of 2013-01-18.
Experiment type: XRAY
Resolution: 2.22 Å
R-factor: 0.202
AEROSPACI score: 0.4 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23458 (1-301)
      • expression tag (0)
    Domains in SCOPe 2.03: d4ei4a_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ei4b_
  • Heterogens: 0Q2, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ei4A (A:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ei4A (A:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkh
iadlkkeieilrnlyhenivkykgictgiklimeflpsgslkeylpknknkinlkqqlky
avqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrds
pvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtr
lvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ei4B (B:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ei4B (B:)
vdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpnhiadlkkeiei
lrnlyhenivkykgictngiklimeflpsgslkeylpknknkinlkqqlkyavqickgmd
ylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapec
lmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegk
rlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk