PDB entry 4ehz

View 4ehz on RCSB PDB site
Description: The Jak1 kinase domain in complex with inhibitor
Class: Transferase/Transferase Inhibitor
Keywords: kinase, Transferase-Transferase Inhibitor complex
Deposited on 2012-04-04, released 2012-07-04
The last revision prior to the SCOPe 2.03 freeze date was dated 2013-01-23, with a file datestamp of 2013-01-18.
Experiment type: XRAY
Resolution: 2.17 Å
R-factor: 0.174
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ehza_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ehzb_
  • Chain 'C':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ehzc_
  • Chain 'D':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4ehzd_
  • Heterogens: JAK, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ehzA (A:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ehzA (A:)
ekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkphiadl
kkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknknkinlkqqlk
yavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrd
spvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvt
rlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4ehzB (B:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ehzB (B:)
vdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpnhiadlkkeiei
lrnlyhenivkykgictngiklimeflpsgslkeylpknknkinlkqqlkyavqickgmd
ylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapec
lmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegk
rlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4ehzC (C:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ehzC (C:)
dpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpnhiadlkkeieil
rnlyhenivkykgictgiklimeflpsgslkeylpknknkinlkqqlkyavqickgmdyl
gsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapeclm
qskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegkrl
pcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4ehzD (D:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4ehzD (D:)
vdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpnhiadlkkeiei
lrnlyhenivkykgictngiklimeflpsgslkeylpknknkinlkqqlkyavqickgmd
ylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapec
lmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegk
rlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk