PDB entry 4efk

View 4efk on RCSB PDB site
Description: Pantothenate synthetase in complex with N,N-DIMETHYLTHIOPHENE-3-SULFONAMIDE
Class: ligase/ligase inhibitor
Keywords: Alpha Beta/3-Layer Sandwich/Rossmann fold, ligase-ligase inhibitor complex
Deposited on 2012-03-29, released 2013-03-13
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-09-04, with a file datestamp of 2013-08-30.
Experiment type: XRAY
Resolution: 1.7 Å
R-factor: 0.173
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Pantothenate synthetase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: MT3707, MTCY07H7B.20, panC, Rv3602c
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4efka_
  • Chain 'B':
    Compound: Pantothenate synthetase
    Species: Mycobacterium tuberculosis [TaxId:1773]
    Gene: MT3707, MTCY07H7B.20, panC, Rv3602c
    Database cross-references and differences (RAF-indexed):
    • Uniprot P0A5R0 (0-End)
      • engineered mutation (1)
    Domains in SCOPe 2.08: d4efkb_
  • Heterogens: 0OC, GOL, EOH, IMD, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4efkA (A:)
maipafhpgelnvysapgdvadvsralrltgrrvmlvptmgalheghlalvraakrvpgs
vvvvsifvnpmqfgaggdldayprtpdddlaqlraegveiaftpttaamypdglrttvqp
gplaaeleggprpthfagvltvvlkllqivrpdrvffgekdyqqlvlirqlvadfnldva
vvgvptvreadglamssrnryldpaqraaavalsaaltaaahaatagaqaaldaaravld
aapgvavdylelrdiglgpmplngsgrllvaarlgttrlldniaieigtfagtdrpdgyr

    Sequence, based on observed residues (ATOM records): (download) 
    >4efkA (A:)
pafhpgelnvysapgdvadvsralrltgrrvmlvptmgalheghlalvraakrvpgsvvv
vsifvnpmqfayprtpdddlaqlraegveiaftpttaamypdglrttvqpgplaaelegg
prpthfagvltvvlkllqivrpdrvffgekdyqqlvlirqlvadfnldvavvgvptvrea
dglamssrnryldpaqraaavalsaaltaaahaatagaqaaldaaravldaapgvavdyl
elrdiglgplngsgrllvaarlgttrlldniaieigtfag

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4efkB (B:)
maipafhpgelnvysapgdvadvsralrltgrrvmlvptmgalheghlalvraakrvpgs
vvvvsifvnpmqfgaggdldayprtpdddlaqlraegveiaftpttaamypdglrttvqp
gplaaeleggprpthfagvltvvlkllqivrpdrvffgekdyqqlvlirqlvadfnldva
vvgvptvreadglamssrnryldpaqraaavalsaaltaaahaatagaqaaldaaravld
aapgvavdylelrdiglgpmplngsgrllvaarlgttrlldniaieigtfagtdrpdgyr

    Sequence, based on observed residues (ATOM records): (download) 
    >4efkB (B:)
maipafhpgelnvysapgdvadvsralrltgrrvmlvptmgalheghlalvraakrvpgs
vvvvsifvnptpdddlaqlraegveiaftpttaamypdglrttvqpgplaaeleggprpt
hfagvltvvlkllqivrpdrvffgekdyqqlvlirqlvadfnldvavvgvptvreadgla
mssrnryldpaqraaavalsaaltaaahaatagaqaaldaaravldaapgvavdylelrd
iglgpmplngsgrllvaarlgttrlldniaieig