PDB entry 4edz

View 4edz on RCSB PDB site
Description: Crystal structure of hH-PGDS with water displacing inhibitor
Class: Isomerase/Isomerase inhibitor
Keywords: Inhibitor, Solvent replacement, Isomerase-Isomerase inhibitor complex
Deposited on 2012-03-27, released 2012-05-16
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-01-02, with a file datestamp of 2012-12-28.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.192
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hematopoietic prostaglandin d synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTS, HPGDS, PGDS, PTGDS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4edza1, d4edza2
  • Chain 'B':
    Compound: hematopoietic prostaglandin d synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTS, HPGDS, PGDS, PTGDS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60760 (1-198)
      • expression tag (0)
    Domains in SCOPe 2.07: d4edzb1, d4edzb2, d4edzb3
  • Chain 'C':
    Compound: hematopoietic prostaglandin d synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTS, HPGDS, PGDS, PTGDS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4edzc1, d4edzc2
  • Chain 'D':
    Compound: hematopoietic prostaglandin d synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTS, HPGDS, PGDS, PTGDS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60760 (1-198)
      • expression tag (0)
    Domains in SCOPe 2.07: d4edzd1, d4edzd2, d4edzd3
  • Heterogens: GSH, 0O5, MG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4edzA (A:)
apnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4edzA (A:)
pnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgltl
hqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnellt
ynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkv
qaipavanwikrrpqtkl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4edzB (B:)
apnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4edzB (B:)
apnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaeqdvkeqmfnellty
naphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkvq
aipavanwikrrpqtkl

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4edzC (C:)
apnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4edzC (C:)
pnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgltl
hqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnellt
ynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkv
qaipavanwikrrpqtkl

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4edzD (D:)
apnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl