PDB entry 4edy

View 4edy on RCSB PDB site
Description: Crystal structure of hH-PGDS with water displacing inhibitor
Class: Isomerase/Isomerase inhibitor
Keywords: Inhibitor, Solvent replacement, Isomerase-Isomerase inhibitor complex
Deposited on 2012-03-27, released 2012-10-03
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-01-02, with a file datestamp of 2012-12-28.
Experiment type: XRAY
Resolution: 1.72 Å
R-factor: 0.176
AEROSPACI score: 0.56 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hematopoietic prostaglandin d synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTS, HPGDS, PGDS, PTGDS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4edya1, d4edya2
  • Chain 'B':
    Compound: hematopoietic prostaglandin d synthase
    Species: Homo sapiens [TaxId:9606]
    Gene: GSTS, HPGDS, PGDS, PTGDS2
    Database cross-references and differences (RAF-indexed):
    • Uniprot O60760 (1-198)
      • expression tag (0)
    Domains in SCOPe 2.07: d4edyb1, d4edyb2, d4edyb3
  • Heterogens: MG, GSH, 9PQ, DMS, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4edyA (A:)
hpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4edyA (A:)
pnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdgltl
hqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnellt
ynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkv
qaipavanwikrrpqtkl

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4edyB (B:)
hpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaekkqdvkeqmfnell
tynaphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkk
vqaipavanwikrrpqtkl

    Sequence, based on observed residues (ATOM records): (download) 
    >4edyB (B:)
hpnykltyfnmrgraeiiryifayldiqyedhrieqadwpeikstlpfgkipilevdglt
lhqslaiaryltkntdlagntemeqchvdaivdtlddfmscfpwaeqdvkeqmfnellty
naphlmqdldtylggrewlignsvtwadfyweicsttllvfkpdlldnhprlvtlrkkvq
aipavanwikrrpqtkl