PDB entry 4edw
View 4edw on RCSB PDB site
Description: Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911 (tanezumab)
Class: immune system
Keywords: cystine knot, immunoglobulin, growth/survival factor, immune system
Deposited on
2012-03-27, released
2014-04-02
The last revision prior to the SCOPe 2.08 freeze date was dated
2017-10-25, with a file datestamp of
2017-10-20.
Experiment type: XRAY
Resolution: 2.48 Å
R-factor: N/A
AEROSPACI score: 0.21
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'H':
Compound: tanezumab Fab heavy chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4edwh1, d4edwh2 - Chain 'L':
Compound: tanezumab Fab light chain
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4edwl1, d4edwl2 - Chain 'V':
Compound: Beta-nerve growth factor
Species: Homo sapiens [TaxId:9606]
Gene: Ngf, Ngfb
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.08: d4edwv_ - Heterogens: GOL, HOH
PDB Chain Sequences:
- Chain 'H':
Sequence, based on SEQRES records: (download)
>4edwH (H:)
qvqlqesgpglvkpsetlsltctvsgfsligydlnwirqppgkglewigiiwgdgttdyn
savksrvtiskdtsknqfslklssvtaadtavyycarggywyatsyyfdywgqgtlvtvs
sastkgpsvfplapcsrstsestaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqs
sglyslssvvtvpssnfgtqtytcnvdhkpsntkvdktverktshhhhhhg
Sequence, based on observed residues (ATOM records): (download)
>4edwH (H:)
qvqlqesgpglvkpsetlsltctvsgfsligydlnwirqppgkglewigiiwgdgttdyn
savksrvtiskdtsknqfslklssvtaadtavyycarggywyatsyyfdywgqgtlvtvs
sastkgpsvfplapcstaalgclvkdyfpepvtvswnsgaltsgvhtfpavlqssglysl
ssvvtvpssnfgtqtytcnvdhkpsntkvdktver
- Chain 'L':
Sequence; same for both SEQRES and ATOM records: (download)
>4edwL (L:)
diqmtqspsslsasvgdrvtitcrasqsisnnlnwyqqkpgkapklliyytsrfhsgvps
rfsgsgsgtdftftisslqpediatyycqqehtlpytfgqgtkleikrtvaapsvfifpp
sdeqlksgtasvvcllnnfypreakvqwkvdnalqsgnsqesvteqdskdstyslsstlt
lskadyekhkvyacevthqglsspvtksfnrgec
- Chain 'V':
Sequence, based on SEQRES records: (download)
>4edwV (V:)
ssshpifhrgefsvcdsvsvwvgdkttatdikgkevmvlgevninnsvfkqyffetkcrd
pnpvdsgcrgidskhwnsycttthtfvkaltmdgkqaawrfiridtacvcvlsrkavrra
Sequence, based on observed residues (ATOM records): (download)
>4edwV (V:)
hrgefsvcdsvsvwvgdkttatdikgkevmvlgevninnsvfkqyffetkcrdpnvdgcr
gidskhwnsycttthtfvkaltmdgkqaawrfiridtacvcvlsrk