PDB entry 4eb8
View 4eb8 on RCSB PDB site
Description: Crystal structure of purine nucleoside phosphorylase (W16Y, W94Y, W178Y, H257W) mutant from human complexed with DADMe-ImmG and phosphate
Class: transferase/transferase inhibitor
Keywords: PNP,Immucillin, purine nucleoside phosphorylase, nucleoside binding, purine base binding, purine-nucleoside phosphorylase activity, drug binding, transferase activity, transferring glycosyl groups, phosphate ion binding, intracellular, cytosol, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-03-23, released
2013-02-06
The last revision prior to the SCOPe 2.08 freeze date was dated
2013-03-13, with a file datestamp of
2013-03-08.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.183
AEROSPACI score: 0.37
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: purine nucleoside phosphorylase
Species: Homo sapiens [TaxId:9606]
Gene: NP, PNP, X00737.1
Database cross-references and differences (RAF-indexed):
- Uniprot P00491 (35-End)
- expression tag (33-34)
- engineered mutation (50)
- engineered mutation (85)
- engineered mutation (128)
- engineered mutation (212)
- engineered mutation (291)
Domains in SCOPe 2.08: d4eb8a1, d4eb8a2 - Chain 'B':
Compound: purine nucleoside phosphorylase
Species: Homo sapiens [TaxId:9606]
Gene: NP, PNP, X00737.1
Database cross-references and differences (RAF-indexed):
- Uniprot P00491 (35-End)
- expression tag (33-34)
- engineered mutation (50)
- engineered mutation (85)
- engineered mutation (128)
- engineered mutation (212)
- engineered mutation (291)
Domains in SCOPe 2.08: d4eb8b1, d4eb8b2 - Chain 'C':
Compound: purine nucleoside phosphorylase
Species: Homo sapiens [TaxId:9606]
Gene: NP, PNP, X00737.1
Database cross-references and differences (RAF-indexed):
- Uniprot P00491
- engineered mutation (50)
- engineered mutation (85)
- engineered mutation (128)
- engineered mutation (212)
- engineered mutation (291)
Domains in SCOPe 2.08: d4eb8c_ - Heterogens: PO4, IM5, EDO, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4eb8A (A:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaeyllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplykvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstykqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanweevlaagk
qaaqkleqfvsilmasiplpdkas
Sequence, based on observed residues (ATOM records): (download)
>4eb8A (A:)
tlmengytyedykntaeyllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
stvpghagrlvfgflngracvmmqgrfhmyegyplykvtfpvrvfhllgvdtlvvtnaag
glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralsty
kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
slitnkvimdyeslekanweevlaagkqaaqkleqfvsilmasiplpd
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4eb8B (B:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaeyllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplykvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstykqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanweevlaagk
qaaqkleqfvsilmasiplpdkas
Sequence, based on observed residues (ATOM records): (download)
>4eb8B (B:)
tlmengytyedykntaeyllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfpr
stvpghagrlvfgflngracvmmqgrfhmyegyplykvtfpvrvfhllgvdtlvvtnaag
glnpkfevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralsty
kqmgeqrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgf
slitnkvimdyeslekanweevlaagkqaaqkleqfvsilmasiplpd
- Chain 'C':
Sequence, based on SEQRES records: (download)
>4eb8C (C:)
mrgshhhhhhgmasmtggqqmgrdlyddddkdptlmengytyedykntaeyllshtkhrp
qvaiicgsglggltdkltqaqifdyseipnfprstvpghagrlvfgflngracvmmqgrf
hmyegyplykvtfpvrvfhllgvdtlvvtnaagglnpkfevgdimlirdhinlpgfsgqn
plrgpnderfgdrfpamsdaydrtmrqralstykqmgeqrelqegtyvmvagpsfetvae
crvlqklgadavgmstvpevivarhcglrvfgfslitnkvimdyeslekanweevlaagk
qaaqkleqfvsilmasiplpdkas
Sequence, based on observed residues (ATOM records): (download)
>4eb8C (C:)
gytyedykntaeyllshtkhrpqvaiicgsglggltdkltqaqifdyseipnfprstvpg
hagrlvfgflngracvmmqgrfhmyegyplykvtfpvrvfhllgvdtlvvtnaagglnpk
fevgdimlirdhinlpgfsgqnplrgpnderfgdrfpamsdaydrtmrqralstykqmge
qrelqegtyvmvagpsfetvaecrvlqklgadavgmstvpevivarhcglrvfgfslitn
kvimdyeslekanweevlaagkqaaqkleqfvsilmasiplpd