PDB entry 4eb4

View 4eb4 on RCSB PDB site
Description: Crystal structure of mouse thymidylate synthase in ternary complex with dUMP and Tomudex
Class: transferase
Keywords: ternary complex, methyltransferase, Nucleotide biosynthesis, TRANSFERASE
Deposited on 2012-03-23, released 2012-05-02
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-05-13, with a file datestamp of 2015-05-08.
Experiment type: XRAY
Resolution: 1.74 Å
R-factor: N/A
AEROSPACI score: 0.39 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Thymidylate synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Tyms
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4eb4a_
  • Chain 'B':
    Compound: Thymidylate synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Tyms
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4eb4b_
  • Chain 'C':
    Compound: Thymidylate synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Tyms
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4eb4c_
  • Chain 'D':
    Compound: Thymidylate synthase
    Species: Mus musculus [TaxId:10090]
    Gene: Tyms
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4eb4d_
  • Heterogens: UMP, D16, DTT, GOL, SO4, MES, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4eb4A (A:)
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >4eb4A (A:)
mlvvgselqsdaqrhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefpl
lttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgp
vygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalp
pchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlg
dahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphptikmemav

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4eb4B (B:)
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >4eb4B (B:)
mlvvgselqsdaqprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefp
llttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlg
pvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmal
ppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtl
gdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphptikmema
v

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4eb4C (C:)
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >4eb4C (C:)
mlvvgselqsdaqrhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefpl
lttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgp
vygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalp
pchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlg
dahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphptik

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4eb4D (D:)
mlvvgselqsdaqqlsaeaprhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqarys
lrdefpllttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsar
qegdlgpvygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkd
lplmalppchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpg
dfvhtlgdahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphpt
ikmemav

    Sequence, based on observed residues (ATOM records): (download) 
    >4eb4D (D:)
mlvvgselqsdaqrhgelqylrqvehilrcgfkkedrtgtgtlsvfgmqaryslrdefpl
lttkrvfwkgvleellwfikgstnakelsskgvriwdangsrdfldslgfsarqegdlgp
vygfqwrhfgaeykdmdsdysgqgvdqlqkvidtiktnpddrriimcawnpkdlplmalp
pchalcqfyvvngelscqlyqrsgdmglgvpfniasyalltymiahitglqpgdfvhtlg
dahiylnhieplkiqlqreprpfpklkilrkvetiddfkvedfqiegynphptikme