PDB entry 4eb1

View 4eb1 on RCSB PDB site
Description: Hyperstable in-frame insertion variant of antithrombin
Class: blood clotting
Keywords: serpin, hydrolase inhibitor, BLOOD CLOTTING
Deposited on 2012-03-23, released 2012-07-18
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.16 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'I':
    Compound: antithrombin-III
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINC1, AT3, PRO0309
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01008 (Start-207)
      • engineered mutation (136)
    • Uniprot P01008 (218-439)
      • insertion (208-217)
    Domains in SCOPe 2.07: d4eb1i_
  • Chain 'L':
    Compound: antithrombin-III
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4eb1l_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'I':
    Sequence, based on SEQRES records: (download)
    >4eb1I (I:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankasklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseainvlvlvntrtstvlvlvntiyfkglwkskfspe
    ntrkelfykadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpeksl
    akvekeltpevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklp
    givaegrddlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfi
    revplntiifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4eb1I (I:)
    vdictakprdipmnpmciyrspenrrvwelskansrfattfyqhladskndndniflspl
    sistafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankasklv
    sanrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktedvipse
    ainvlvlvntrtstvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegk
    fryrrvaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlv
    vhmprfriedgfslkeqlqdmglvdlfspeksklpgivadlyvsdafhkaflevneegse
    aaastavviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcvk
    

  • Chain 'L':
    Sequence, based on SEQRES records: (download)
    >4eb1L (L:)
    hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
    tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
    fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
    qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
    kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
    pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
    dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
    ifmgrvanpcvk
    

    Sequence, based on observed residues (ATOM records): (download)
    >4eb1L (L:)
    ictakpipmnpmciytnrrvwelskansrfattfyqhladskndndniflsplsistafa
    mtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkssklvsanrlfgdks
    ltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegritdvipseainelt
    vlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkfryrrvaegtqvle
    lpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvvhmprfriedgfsl
    keqlqdmglvdlfspeksklpgivaerddlyvsdafhkaflevneegseaaastavviag
    rslfkanrpflvfirevplntiifmgrvanpc