PDB entry 4eb1

View 4eb1 on RCSB PDB site
Description: Hyperstable in-frame insertion variant of antithrombin
Class: blood clotting
Keywords: serpin, hydrolase inhibitor, BLOOD CLOTTING
Deposited on 2012-03-23, released 2012-07-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2020-07-29, with a file datestamp of 2020-07-04.
Experiment type: XRAY
Resolution: 2.8 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'I':
    Compound: antithrombin-III
    Species: Homo sapiens [TaxId:9606]
    Gene: SERPINC1, AT3, PRO0309
    Database cross-references and differences (RAF-indexed):
    • Uniprot P01008 (Start-207)
      • engineered mutation (136)
    • Uniprot P01008 (218-439)
      • insertion (208-217)
    Domains in SCOPe 2.08: d4eb1i_
  • Chain 'L':
    Compound: antithrombin-III
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4eb1l_
  • Heterogens: NAG, HOH

PDB Chain Sequences:

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4eb1I (I:)
hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
fffaklncrlyrkankasklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
qsraainkwvsnktegritdvipseainvlvlvntrtstvlvlvntiyfkglwkskfspe
ntrkelfykadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpeksl
akvekeltpevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklp
givaegrddlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfi
revplntiifmgrvanpcvk

    Sequence, based on observed residues (ATOM records): (download) 
    >4eb1I (I:)
vdictakprdipmnpmciyrspenrrvwelskansrfattfyqhladskndndniflspl
sistafamtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkankasklv
sanrlfgdksltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktedvipse
ainvlvlvntrtstvlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegk
fryrrvaegtqvlelpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlv
vhmprfriedgfslkeqlqdmglvdlfspeksklpgivadlyvsdafhkaflevneegse
aaastavviagrslnpnrvtfkanrpflvfirevplntiifmgrvanpcvk

  • Chain 'L':
    Sequence, based on SEQRES records: (download) 
    >4eb1L (L:)
hgspvdictakprdipmnpmciyrspekkatedegseqkipeatnrrvwelskansrfat
tfyqhladskndndniflsplsistafamtklgacndtlqqlmevfkfdtisektsdqih
fffaklncrlyrkankssklvsanrlfgdksltfnetyqdiselvygaklqpldfkenae
qsraainkwvsnktegritdvipseaineltvlvlvntiyfkglwkskfspentrkelfy
kadgescsasmmyqegkfryrrvaegtqvlelpfkgdditmvlilpkpekslakvekelt
pevlqewldeleemmlvvhmprfriedgfslkeqlqdmglvdlfspeksklpgivaegrd
dlyvsdafhkaflevneegseaaastavviagrslnpnrvtfkanrpflvfirevplnti
ifmgrvanpcvk

    Sequence, based on observed residues (ATOM records): (download) 
    >4eb1L (L:)
ictakpipmnpmciytnrrvwelskansrfattfyqhladskndndniflsplsistafa
mtklgacndtlqqlmevfkfdtisektsdqihfffaklncrlyrkssklvsanrlfgdks
ltfnetyqdiselvygaklqpldfkenaeqsraainkwvsnktegritdvipseainelt
vlvlvntiyfkglwkskfspentrkelfykadgescsasmmyqegkfryrrvaegtqvle
lpfkgdditmvlilpkpekslakvekeltpevlqewldeleemmlvvhmprfriedgfsl
keqlqdmglvdlfspeksklpgivaerddlyvsdafhkaflevneegseaaastavviag
rslfkanrpflvfirevplntiifmgrvanpc