PDB entry 4e8o

View 4e8o on RCSB PDB site
Description: Crystal structure of aminoglycoside antibiotic 6'-N-acetyltransferase AAC(6')-Ih from Acinetobacter baumannii
Class: transferase
Keywords: antibiotic resistance, Center for Structural Genomics of Infectious Diseases (CSGID), NIAID, National Institute of Allergy and Infectious Diseases, GNAT superfamily, GCN5-related N-acetyltransferase superfamily, N-acetyltransferase fold, aminoglycoside antibiotic 6'-N-acetyltransferase, aminoglycoside antibiotics, acetyl coenzyme A, coenzyme A, intracellular, TRANSFERASE
Deposited on 2012-03-20, released 2012-04-04
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-02-22, with a file datestamp of 2017-02-17.
Experiment type: XRAY
Resolution: 2.14 Å
R-factor: N/A
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aac(6')-Ih protein
    Species: Acinetobacter baumannii [TaxId:470]
    Gene: aac(6')-Ih
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q43899 (21-166)
      • expression tag (20)
    Domains in SCOPe 2.07: d4e8oa1, d4e8oa2
  • Chain 'B':
    Compound: Aac(6')-Ih protein
    Species: Acinetobacter baumannii [TaxId:470]
    Gene: aac(6')-Ih
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q43899 (21-166)
      • expression tag (19-20)
    Domains in SCOPe 2.07: d4e8ob1, d4e8ob2
  • Heterogens: CL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e8oA (A:)
mgsshhhhhhssgrenlyfqgmnimpisesqlsdwlalrcllwpdhedvhlqemrqlitq
ahrlqllaytdtqqaiamleasiryeyvngtqtspvaflegifvlpeyrrsgiatglvqq
veiwakqfactefasdaaldnqishamhqalgfhetervvyfkknig

    Sequence, based on observed residues (ATOM records): (download) 
    >4e8oA (A:)
gmnimpisesqlsdwlalrcllwpdhedvhlqemrqlitqahrlqllaytdtqqaiamle
asiryeyvngtqtspvaflegifvlpeyrrsgiatglvqqveiwakqfactefasdaald
nqishamhqalgfhetervvyfkknig

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4e8oB (B:)
mgsshhhhhhssgrenlyfqgmnimpisesqlsdwlalrcllwpdhedvhlqemrqlitq
ahrlqllaytdtqqaiamleasiryeyvngtqtspvaflegifvlpeyrrsgiatglvqq
veiwakqfactefasdaaldnqishamhqalgfhetervvyfkknig

    Sequence, based on observed residues (ATOM records): (download) 
    >4e8oB (B:)
qgmnimpisesqlsdwlalrcllwpdhedvhlqemrqlitqahrlqllaytdtqqaiaml
easiryeyvngtqtspvaflegifvlpeyrrsgiatglvqqveiwakqfactefasdaal
dnqishamhqalgfhetervvyfkknig