PDB entry 4e78

View 4e78 on RCSB PDB site
Description: Crystal structure of a product state assembly of HCV NS5B genotype 2a JFH-1 isolate with beta hairpin loop deletion bound to primer-template RNA with 3'-dG
Class: viral protein, transferase/RNA
Keywords: RDRP, loopless DELTA8, ternary complex, product complex, Flaviviridae, hepatitis C virus, VIRAL PROTEIN, TRANSFERASE-RNA complex
Deposited on 2012-03-16, released 2012-04-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2017-07-26, with a file datestamp of 2017-07-21.
Experiment type: XRAY
Resolution: 2.9 Å
R-factor: N/A
AEROSPACI score: 0.14 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: protein (RNA-directed RNA polymerase)
    Species: Hepatitis C virus [TaxId:356411]
    Gene: NS5B
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q99IB8 (2-444)
      • expression tag (1)
      • engineered mutation (87-88)
    • Uniprot Q99IB8 (447-End)
      • linker (445-446)
    Domains in SCOPe 2.08: d4e78a1, d4e78a2
  • Chain 'P':
    Compound: 5'-r(*u*ap*cp*cp*gp*(gdo))-3'
  • Chain 'T':
    Compound: 5'-r(*u*ap*cp*cp*gp*(gdo))-3'
  • Heterogens: HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e78A (A:)
mssmsyswtgalitpcspeeeklpinplsnsllryhnkvycttsksasqrakkvtfdrtq
vldahydsvlkdiklaaskvsarlltlqqacqltpphsarskygfgakevrslsgravnh
iksvwkdlledpqtpipttimaknevfcvdpakggkkparlivypdlgvrvcekmalydi
tqklpqavmgasygfqyspaqrveyllkawaekkdpmgfsydtrcfdstvterdirtees
iyqacslpeeartaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvk
alaackaagivaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpey
dlelitscssnvsvalgprgrrryyltrdpttplaraawetvrhspinswlgniiqyapt
iwvrmvlmthffsilmvqdtldqnlggvnpldlpaiierlhgldafsmhtyshheltrva
salrklgapplrvwksraravraslisrggkaavcgrylfnwavktklkltplpearlld
lsswftvgagggdifhsvsrarprlehhhhhh

    Sequence, based on observed residues (ATOM records): (download) 
    >4e78A (A:)
ssmsyswtgalitpcspeeeklpinplsnsllryhnkvycttsksasqrakkvtfdrtqv
ldahydsvlkdiklaaskvsarlltlqqacqltpphsarskygfgakevrslsgravnhi
ksvwkdlledpqtpipttimaknevfcvdpakggkkparlivypdlgvrvcekmalydit
qklpqavmgasygfqyspaqrveyllkawaekkdpmgfsydtrcfdstvterdirteesi
yqacslpeeartaihslterlyvggpmfnskgqtcgyrrcrasgvlttsmgntitcyvka
laackaagivaptmlvcgddlvvisesqgteedernlrafteamtrysappgdpprpeyd
lelitscssnvsvalgprgrrryyltrdpttplaraawetvrhspinswlgniiqyapti
wvrmvlmthffsilmvqdtldqnlggvnpldlpaiierlhgldafsmhtyshheltrvas
alrklgapplrvwksraravraslisrggkaavcgrylfnwavktklkltplpearll

  • Chain 'P':
    No sequence available.

  • Chain 'T':
    No sequence available.