PDB entry 4e5w

View 4e5w on RCSB PDB site
Description: JAK1 kinase (JH1 domain) in complex with compound 26
Class: transferase/transferase inhibitor
Keywords: JAK1, kinase domain, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-03-14, released 2012-05-30
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-07-11, with a file datestamp of 2012-07-06.
Experiment type: XRAY
Resolution: 1.86 Å
R-factor: 0.184
AEROSPACI score: 0.5 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed):
    • Uniprot P23458 (1-301)
      • expression tag (0)
    Domains in SCOPe 2.05: d4e5wa_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.05: d4e5wb_
  • Heterogens: 0NT, PEG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e5wA (A:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4e5wA (A:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkn
hiadlkkeieilrnlyhenivkykgictengiklimeflpsgslkeylpknknkinlkqq
lkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkdd
rdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmt
vtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4e5wB (B:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4e5wB (B:)
vdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpnhiadlkkeiei
lrnlyhenivkykgictengiklimeflpsgslkeylpknknkinlkqqlkyavqickgm
dylgsrqyvhrdlaarnvlvesehqvkigdfgltkaiekeyytvkddrdspvfwyapecl
mqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegkr
lpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeall