PDB entry 4e4l

View 4e4l on RCSB PDB site
Description: JAK1 kinase (JH1 domain) in complex with compound 30
Class: transferase/transferase inhibitor
Keywords: o-phosphotyrosine, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-03-13, released 2012-05-30
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-07-11, with a file datestamp of 2012-07-06.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.191
AEROSPACI score: 0.46 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4e4la_
  • Chain 'B':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4e4lb_
  • Chain 'D':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4e4ld_
  • Chain 'E':
    Compound: Tyrosine-protein kinase JAK1
    Species: Homo sapiens [TaxId:9606]
    Gene: JAK1, JAK1A, JAK1B
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.06: d4e4le_
  • Heterogens: 0NH, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e4lA (A:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4lA (A:)
vdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkhiadlkkeieilr
nlyhenivkykgictgiklimeflpsgslkeylpknknkinlkqqlkyavqickgmdylg
srqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapeclmq
skfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegkrlp
cppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4e4lB (B:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4lB (B:)
evdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslknhiadlkkeiei
lrnlyhenivkykgictgiklimeflpsgslkeylpknknkinlkqqlkyavqickgmdy
lgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapecl
mqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegkr
lpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4e4lD (D:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4lD (D:)
evdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkhiadlkkeieil
rnlyhenivkykgictggngiklimeflpsgslkeylpknknkinlkqqlkyavqickgm
dylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyape
clmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkeg
krlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4e4lE (E:)
gdivsekkpatevdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkp
esggnhiadlkkeieilrnlyhenivkykgictedggngiklimeflpsgslkeylpknk
nkinlkqqlkyavqickgmdylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdk
eyytvkddrdspvfwyapeclmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmi
gpthgqmtvtrlvntlkegkrlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeal
lk

    Sequence, based on observed residues (ATOM records): (download) 
    >4e4lE (E:)
evdpthfekrflkrirdlgeghfgkvelcrydpegdntgeqvavkslkpnhiadlkkeie
ilrnlyhenivkykgictgiklimeflpsgslkeylpknknkinlkqqlkyavqickgmd
ylgsrqyvhrdlaarnvlvesehqvkigdfgltkaietdkeyytvkddrdspvfwyapec
lmqskfyiasdvwsfgvtlhelltycdsdsspmalflkmigpthgqmtvtrlvntlkegk
rlpcppncpdevyqlmrkcwefqpsnrtsfqnliegfeallk