PDB entry 4e41

View 4e41 on RCSB PDB site
Description: Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Class: immune system
Keywords: Ig domain, adaptive immunity, T cell receptor, MHC, IMMUNE SYSTEM
Deposited on 2012-03-11, released 2012-08-29
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-08-29, with a file datestamp of 2012-08-24.
Experiment type: XRAY
Resolution: 2.6 Å
R-factor: 0.201
AEROSPACI score: 0.3 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4e41a1, d4e41a2
  • Chain 'B':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4e41b1, d4e41b2
  • Chain 'C':
    Compound: triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60174 (0-14)
      • conflict (5)
  • Chain 'D':
    Compound: T cell receptor G4 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4E41 (0-End)
    Domains in SCOPe 2.04: d4e41d1, d4e41d2
  • Chain 'E':
    Compound: T cell receptor G4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4E41 (0-End)
    Domains in SCOPe 2.04: d4e41e1, d4e41e2
  • Chain 'F':
    Compound: hla class II histocompatibility antigen, dr alpha chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRA, HLA-DRA1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4e41f1, d4e41f2
  • Chain 'G':
    Compound: HLA class II histocompatibility antigen, DRB1-1 beta chain
    Species: Homo sapiens [TaxId:9606]
    Gene: HLA-DRB1
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4e41g1, d4e41g2
  • Chain 'H':
    Compound: triosephosphate isomerase
    Species: Homo sapiens [TaxId:9606]
    Gene: TPI1, TPI
    Database cross-references and differences (RAF-indexed):
    • Uniprot P60174 (0-14)
      • conflict (5)
  • Chain 'I':
    Compound: T cell receptor G4 alpha chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4E41 (0-End)
    Domains in SCOPe 2.04: d4e41i1, d4e41i2
  • Chain 'J':
    Compound: T cell receptor G4 beta chain
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • PDB 4E41 (0-End)
    Domains in SCOPe 2.04: d4e41j1, d4e41j2
  • Heterogens: NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e41A (A:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >4e41A (A:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4e41B (B:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records): (download) 
    >4e41B (B:)
rprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywns
qkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsnllvcsvsgfypgsievrw
frngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsvtspltvewra

  • Chain 'C':
    No sequence available.

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4e41D (D:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcavdrgstlgrlyfgrgtqltvwpdiqkpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >4e41D (D:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcavdrgstlgrlyfgrgtqltvwpdiqkpdpavyq
lrdsvclftdfdsqtnvsqyitdkcvldmrsmdfksnsavawsacanafnsiipedtffp
s

  • Chain 'E':
    Sequence, based on SEQRES records: (download) 
    >4e41E (E:)
gvtqspthliktrgqqatlrcspisghtsvywyqqalglglqfllwydegeernrgnfpp
rfsgrqfpnysselnvnaleledsalylcassqiretqyfgpgtrllvledlknvfppev
avfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpalnd
sryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >4e41E (E:)
gvtqspthliktrgqqatlrcspisghtsvywyqqalglqfllwydegeernrgnfpprf
sgrqfpnysselnvnaleledsalylcassqiretqyfgpgtrllvledlknvfppevav
fepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpalndsr
yalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra

  • Chain 'F':
    Sequence, based on SEQRES records: (download) 
    >4e41F (F:)
ikeehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgal
aniavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvt
wlrngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwef
da

    Sequence, based on observed residues (ATOM records): (download) 
    >4e41F (F:)
eehviiqaefylnpdqsgefmfdfdgdeifhvdmakketvwrleefgrfasfeaqgalan
iavdkanleimtkrsnytpitnvppevtvltnspvelrepnvlicfidkftppvvnvtwl
rngkpvttgvsetvflpredhlfrkfhylpflpstedvydcrvehwgldepllkhwefd

  • Chain 'G':
    Sequence, based on SEQRES records: (download) 
    >4e41G (G:)
gdtrprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaey
wnsqkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsktqplqhhnllvcsvs
gfypgsievrwfrngqeekagvvstgliqngdwtfqtlvmletvprsgevytcqvehpsv
tspltvewra

    Sequence, based on observed residues (ATOM records): (download) 
    >4e41G (G:)
rprflwqlkfechffngtervrllerciynqeesvrfdsdvgeyravtelgrpdaeywns
qkdlleqrraavdtycrhnygvgesftvqrrvepkvtvypsnllvcsvsgfypgsievrw
frngqeekagvvstgliqngdwtfqtlvmletvsgevytcqvehpsvtspltvewra

  • Chain 'H':
    No sequence available.

  • Chain 'I':
    Sequence, based on SEQRES records: (download) 
    >4e41I (I:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcavdrgstlgrlyfgrgtqltvwpdiqkpdpavyq
lrdskssdksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnksdf
acanafnnsiipedtffpspess

    Sequence, based on observed residues (ATOM records): (download) 
    >4e41I (I:)
iqveqsppdlilqeganstlrcnfsdsvnnlqwfhqnpwgqlinlfyipsgtkqngrlsa
ttvaterysllyisssqttdsgvyfcavdrgstlgrlyfgrgtqltvwpdiqkpdpavyq
lrdsksvclftdfdsqtnvsqskdsdvyitdkcvldmrsmdfksnsavawsnacanafnn
siipedtffp

  • Chain 'J':
    Sequence, based on SEQRES records: (download) 
    >4e41J (J:)
gvtqspthliktrgqqatlrcspisghtsvywyqqalglglqfllwydegeernrgnfpp
rfsgrqfpnysselnvnaleledsalylcassqiretqyfgpgtrllvledlknvfppev
avfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpalnd
sryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgrad

    Sequence, based on observed residues (ATOM records): (download) 
    >4e41J (J:)
gvtqspthliktrgqqatlrcspisghtsvywyqqalglglqfllwydegeernrgnfpp
rfsgrqfpnysselnvnaleledsalylcassqiretqyfgpgtrllvledlknvfppev
avfepseaeishtqkatlvclatgfypdhvelswwvngkevhsgvctdpqplkeqpalnd
sryalssrlrvsatfwqnprnhfrcqvqfyglsendewtqdrakpvtqivsaeawgra