PDB entry 4e1z

View 4e1z on RCSB PDB site
Description: Structure of mouse Tyk-2 complexed to a 3-aminoindazole inhibitor
Class: transferase/transferase inhibitor
Keywords: kinase catalytic domain, kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-03-07, released 2012-10-03
The last revision prior to the SCOPe 2.06 freeze date was dated 2012-10-03, with a file datestamp of 2012-09-28.
Experiment type: XRAY
Resolution: 2.5 Å
R-factor: 0.199
AEROSPACI score: 0.32 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Non-receptor tyrosine-protein kinase TYK2
    Species: Mus musculus [TaxId:10090]
    Gene: TYK2
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9R117 (0-290)
      • engineered mutation (136)
    Domains in SCOPe 2.06: d4e1za_
  • Heterogens: 0MX, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e1zA (A:)
sdptvfhkrylkkirdlgeghfgkvslycydptndgtgemvavkalkegcgpqlrsgwqr
eieilrtlyhehivkykgccedqgeksvqlvmeyvplgslrdylprhcvglaqlllfaqq
icegmaylhaqhyihralaarnvlldndrlvkigdfglakavpegheyyrvredgdspvf
wyapeclkeckfyyasdvwsfgvtlyelltycdsnqsphtkftelightqgqmtvlrlte
llergerlprpdrcpceiyhlmkncweteasfrptfqnlvpilqtaqekyq

    Sequence, based on observed residues (ATOM records): (download) 
    >4e1zA (A:)
sdptvfhkrylkkirdlgeghfgkvslycydptndgtgemvavkalkegcgpqlrsgwqr
eieilrtlyhehivkykgccedksvqlvmeyvplgslrdylprhcvglaqlllfaqqice
gmaylhaqhyihralaarnvlldndrlvkigdfglakavpegheyyrvredgdspvfwya
peclkeckfyyasdvwsfgvtlyelltycdsnqsphtkftelightqgqmtvlrltelle
rgerlprpdrcpceiyhlmkncweteasfrptfqnlvpilqtaqekyq