PDB entry 4e1l

View 4e1l on RCSB PDB site
Description: Crystal structure of Acetoacetyl-CoA thiolase (thlA2) from Clostridium difficile
Class: transferase
Keywords: 3-layer(aba) sandwich, thiolase, TRANSFERASE
Deposited on 2012-03-06, released 2012-03-21
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-03-21, with a file datestamp of 2012-03-16.
Experiment type: XRAY
Resolution: 2 Å
R-factor: 0.176
AEROSPACI score: 0.47 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Acetoacetyl-CoA thiolase 2
    Species: Clostridium difficile [TaxId:272563]
    Gene: thlA2, CD630_26760
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q183B0 (3-394)
      • expression tag (1-2)
    Domains in SCOPe 2.05: d4e1la1, d4e1la2
  • Chain 'B':
    Compound: Acetoacetyl-CoA thiolase 2
    Species: Clostridium difficile [TaxId:272563]
    Gene: thlA2, CD630_26760
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q183B0 (3-394)
      • expression tag (2)
    Domains in SCOPe 2.05: d4e1lb1, d4e1lb2
  • Chain 'C':
    Compound: Acetoacetyl-CoA thiolase 2
    Species: Clostridium difficile [TaxId:272563]
    Gene: thlA2, CD630_26760
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q183B0 (3-394)
      • expression tag (1-2)
    Domains in SCOPe 2.05: d4e1lc1, d4e1lc2
  • Chain 'D':
    Compound: Acetoacetyl-CoA thiolase 2
    Species: Clostridium difficile [TaxId:272563]
    Gene: thlA2, CD630_26760
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q183B0 (3-394)
      • expression tag (2)
    Domains in SCOPe 2.05: d4e1ld1, d4e1ld2
  • Heterogens: IOD, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4e1lA (A:)
snamkdvvivsavrtpigsfggvfkntsavqlgtiavkeaisrvglnlseideviignvl
qtglgqnvarqiainagipnsvpsytvnklcgsglksvqlaaqsitsgendvviaggten
msqapyivptarfgskmgnitmvdsmltdglidafnqyhmgitaeniatkfeftremqdk
lalesqnkaenaiknnrfkeeivpvdvlirrgkietidkdeypklgmtfeglsklkpafk
kdgtvtagnasgindgaamlilmsqqkadelgirplakiksyasagvepevmgtgpipat
rkalkkaglsindidlieaneafaaqalavknelqidssklnvnggaialghpigasgar
ilvtliyemqkrkvetglatlcigggqgismvvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4e1lA (A:)
namkdvvivsavrtpigsfggvfkntsavqlgtiavkeaisrvglnlseideviignvlq
tglgqnvarqiainagipnsvpsytvnklcgsglksvqlaaqsitsgendvviaggtenm
sqapyivptarfgskmgniltdglidafnqyhmgitaeniatkfeftremqdklalesqn
kaenaiknnrfkeeivpvdvlirrgkietidkdeypklgmtfeglsklkpafkkdgtvta
gnasgindgaamlilmsqqkadelgirplakiksyasagvepevmgtgpipatrkalkka
glsindidlieaneafaaqalavknelqidssklnvnggaialghpigasgarilvtliy
emqkrkvetglatlcigggqgismvvsr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4e1lB (B:)
snamkdvvivsavrtpigsfggvfkntsavqlgtiavkeaisrvglnlseideviignvl
qtglgqnvarqiainagipnsvpsytvnklcgsglksvqlaaqsitsgendvviaggten
msqapyivptarfgskmgnitmvdsmltdglidafnqyhmgitaeniatkfeftremqdk
lalesqnkaenaiknnrfkeeivpvdvlirrgkietidkdeypklgmtfeglsklkpafk
kdgtvtagnasgindgaamlilmsqqkadelgirplakiksyasagvepevmgtgpipat
rkalkkaglsindidlieaneafaaqalavknelqidssklnvnggaialghpigasgar
ilvtliyemqkrkvetglatlcigggqgismvvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4e1lB (B:)
amkdvvivsavrtpigsfggvfkntsavqlgtiavkeaisrvglnlseideviignvlqt
glgqnvarqiainagipnsvpsytvnklcgsglksvqlaaqsitsgendvviaggtenms
qapyivptarfgskmgtdglidafnqyhmgitaeniatkfeftremqdklalesqnkaen
aiknnrfkeeivpvdvlirrgkietidkdeypklgmtfeglsklkpafkkdgtvtagnas
gindgaamlilmsqqkadelgirplakiksyasagvepevmgtgpipatrkalkkaglsi
ndidlieaneafaaqalavknelqidssklnvnggaialghpigasgarilvtliyemqk
rkvetglatlcigggqgismvvsr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4e1lC (C:)
snamkdvvivsavrtpigsfggvfkntsavqlgtiavkeaisrvglnlseideviignvl
qtglgqnvarqiainagipnsvpsytvnklcgsglksvqlaaqsitsgendvviaggten
msqapyivptarfgskmgnitmvdsmltdglidafnqyhmgitaeniatkfeftremqdk
lalesqnkaenaiknnrfkeeivpvdvlirrgkietidkdeypklgmtfeglsklkpafk
kdgtvtagnasgindgaamlilmsqqkadelgirplakiksyasagvepevmgtgpipat
rkalkkaglsindidlieaneafaaqalavknelqidssklnvnggaialghpigasgar
ilvtliyemqkrkvetglatlcigggqgismvvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4e1lC (C:)
namkdvvivsavrtpigsfggvfkntsavqlgtiavkeaisrvglnlseideviignvlq
tglgqnvarqiainagipnsvpsytvnklcgsglksvqlaaqsitsgendvviaggtenm
sqapyivpyhmgitaeniatkfeftremqdklalesqnkaenaiknnrfkeeivpvdvlg
kietidkdeypklgmtfeglsklkpafkkdgtvtagnasgindgaamlilmsqqkadelg
irplakiksyasagvepevmgtgpipatrkalkkaglsindidlieaneafaaqalavkn
elqidssklnvnggaialghpigasgarilvtliyemqkrkvetglatlcigggqgismv
vsr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4e1lD (D:)
snamkdvvivsavrtpigsfggvfkntsavqlgtiavkeaisrvglnlseideviignvl
qtglgqnvarqiainagipnsvpsytvnklcgsglksvqlaaqsitsgendvviaggten
msqapyivptarfgskmgnitmvdsmltdglidafnqyhmgitaeniatkfeftremqdk
lalesqnkaenaiknnrfkeeivpvdvlirrgkietidkdeypklgmtfeglsklkpafk
kdgtvtagnasgindgaamlilmsqqkadelgirplakiksyasagvepevmgtgpipat
rkalkkaglsindidlieaneafaaqalavknelqidssklnvnggaialghpigasgar
ilvtliyemqkrkvetglatlcigggqgismvvsr

    Sequence, based on observed residues (ATOM records): (download) 
    >4e1lD (D:)
amkdvvivsavrtpigsfggvfkntsavqlgtiavkeaisrvglnlseideviignvlqt
glgqnvarqiainagipnsvpsytvnklcgsglksvqlaaqsitsgendvviaggtenms
qapyiqyhmgitaeniatkfeftremqdklalesqnkaenaiknnrfkeeivpvdvlirr
gkietidkdeypklgmtfeglsklkpafkkdgtvtagnasgindgaamlilmsqqkadel
girplakiksyasagvepevmgtgpipatrkalkkaglsindidlieaneafaaqalavk
nelqidssklnvnggaialghpigasgarilvtliyemqkrkvetglatlcigggqgism
vvsr