PDB entry 4dym

View 4dym on RCSB PDB site
Description: Crystal structure of the ACVR1 kinase domain in complex with the imidazo[1,2-b]pyridazine inhibitor K00135
Class: transferase/transferase inhibitor
Keywords: Structural Genomics, Structural Genomics Consortium, SGC, Protein Kinase, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-02-29, released 2012-03-21
The last revision prior to the SCOPe 2.04 freeze date was dated 2012-03-21, with a file datestamp of 2012-03-16.
Experiment type: XRAY
Resolution: 2.42 Å
R-factor: 0.223
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Activin receptor type-1
    Species: Homo sapiens [TaxId:9606]
    Gene: ACVR1, ACVRLK2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.04: d4dyma_
  • Heterogens: SO4, IYZ, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dymA (A:)
smqrtvahqitllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlr
henilgfiasdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglah
lhieifgtqgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgt
krymapevldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpnd
psfedmrkvvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltki
d

    Sequence, based on observed residues (ATOM records): (download) 
    >4dymA (A:)
qitllecvgkgrygevwrgswqgenvavkifssrdekswfretelyntvmlrhenilgfi
asdmtsrhsstqlwlithyhemgslydylqlttldtvsclrivlsiasglahlhieifgt
qgkpaiahrdlksknilvkkngqcciadlglavmhsqstnqldvgnnprvgtkrymapev
ldetiqvdcfdsykrvdiwafglvlwevarrmvsngivedykppfydvvpndpsfedmrk
vvcvdqqrpnipnrwfsdptltslaklmkecwyqnpsarltalrikktltkid