PDB entry 4dv8

View 4dv8 on RCSB PDB site
Description: Anthrax Lethal Factor metalloproteinase in complex with the Hydroxamic acid based small molecule PT8421
Class: hydrolase
Keywords: endopeptidase, Zinc dependent, HYDROLASE
Deposited on 2012-02-22, released 2012-03-14
The last revision prior to the SCOPe 2.07 freeze date was dated 2017-11-15, with a file datestamp of 2017-11-10.
Experiment type: XRAY
Resolution: 1.63 Å
R-factor: N/A
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Lethal Factor
    Species: Bacillus anthracis [TaxId:1392]
    Gene: lef, pXO1-107, BXA0172, GBAA_pXO1_0172
    Database cross-references and differences (RAF-indexed):
    • Uniprot P15917 (Start-525)
      • conflict (15)
    Domains in SCOPe 2.07: d4dv8a1, d4dv8a2
  • Heterogens: ZN, 0LX, MLI, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dv8A (A:)
mrgshhhhhhgsrmlsryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihs
lsqeekellkriqidssdflsteekeflkklqidirdslseeekellnriqvdssnplse
kekeflkklkldiqpydinqrlqdtgglidspsinldvrkqykrdiqnidallhqsigst
lynkiylyenmninnltatlgadlvdstdntkinrgifnefkknfkysissnymivdine
rpaldnerlkwriqlspdtragylengklilqrnigleikdvqiikqsekeyiridakvv
pkskidtkiqeaqlninqewnkalglpkytklitfnvhnryasnivesaylilnewknni
qsdlikkvtnylvdgngrfvftditlpniaeqythqdeiyeqvhskglyvpesrsillhg
pskgvelrndsegfihefghavddyagylldknqsdlvtnskkfidifkeegsnltsygr
tneaeffaeafrlmhstdhaerlkvqknapktfqfindqikfiins

    Sequence, based on observed residues (ATOM records): (download) 
    >4dv8A (A:)
lsryekwekikqhyqhwsdslseegrgllkklqipiepkkddiihslsqeekellkriqi
dssdflsteekeflkklqidirdslseeekellnriqvdssnplsekekeflkklkldiq
pydinqrlqdtgglidspsinldvrkqykrdiqnidallhqsigstlynkiylyenmnin
nltatlgadlvdstdntkinrgifnefkknfkysissnymivdinerpaldnerlkwriq
lspdtragylengklilqrnigleikdvqiikqsekeyiridakvvpkskidtkiqeaql
ninqewnkalglpkytklitfnvhnryasnivesaylilnewknniqsdlikkvtnylvd
gngrfvftditlpniaeqythqdeiyeqvhskglyvpesrsillhgpskgvelrndsegf
ihefghavddyagylldknqsdlvtnskkfidifkeegsnltsygrtneaeffaeafrlm
hstdhaerlkvqknapktfqfindqikfiins