PDB entry 4dru

View 4dru on RCSB PDB site
Description: HCV NS5B in complex with macrocyclic INDOLE INHIBITOR
Class: Transferase/Inhibitor
Keywords: HCV POLYMERASE, macrocycle inhibitor, thumb domain, Transferase-Inhibitor complex
Deposited on 2012-02-17, released 2012-04-18
The last revision prior to the SCOPe 2.08 freeze date was dated 2012-08-15, with a file datestamp of 2012-08-10.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.185
AEROSPACI score: 0.44 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:420174]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4drua_
  • Chain 'B':
    Compound: RNA-directed RNA polymerase
    Species: Hepatitis C virus [TaxId:420174]
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4drub_
  • Heterogens: 0LN, SO4, GOL, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4druA (A:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhs

    Sequence, based on observed residues (ATOM records): (download) 
    >4druA (A:)
smsytwtgalitpcaaeesklphhnmvyattsrsaslrqkkvtfdrlqvlddhyrdvlke
mkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhirsvwedlledt
etpidttimaksevfcvqgrkparlivfpdlgvrvcekmalydvvstlpqavmgssygfq
yspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccdlapearqair
slterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacraaklqdctml
vngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelitscssnvsvah
dasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmilmthffsill
aqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinrvasclrklgv
pplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaasqldlsgwfvag
ysggdiyhs

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4druB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqpekggrkparlivfpdlgvrvcekmalydvvs
tlpqavmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiy
qccdlapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkat
aacraaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydl
elitscssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlw
armilmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspg
einrvasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpip
aasqldlsgwfvagysggdiyhs

    Sequence, based on observed residues (ATOM records): (download) 
    >4druB (B:)
smsytwtgalitpcaaeesklpinplsnsllrhhnmvyattsrsaslrqkkvtfdrlqvl
ddhyrdvlkemkakastvkakllsieeackltpphsakskfgygakdvrnlssravnhir
svwedlledtetpidttimaksevfcvqgrkparlivfpdlgvrvcekmalydvvstlpq
avmgssygfqyspkqrveflvntwkskkcpmgfsydtrcfdstvtesdirveesiyqccd
lapearqairslterlyiggpltnskgqncgyrrcrasgvlttscgntltcylkataacr
aaklqdctmlvngddlvvicesagtqedaaalrafteamtrysappgdppqpeydlelit
scssnvsvahdasgkrvyyltrdpttplaraawetarhtpinswlgniimyaptlwarmi
lmthffsillaqeqlekaldcqiygacysiepldlpqiierlhglsaftlhsyspgeinr
vasclrklgvpplrtwrhrarsvrakllsqggraatcgrylfnwavrtklkltpipaasq
ldlsgwfvagysggdiyhs