PDB entry 4drj

View 4drj on RCSB PDB site
Description: o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
Class: Isomerase/Transferase
Keywords: Fk-506 binding domain, Hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, kinase, signalling, mammalian target of Rapamycin, immunosuppression, cancer, Isomerase-Transferase complex
Deposited on 2012-02-17, released 2013-02-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-03-27, with a file datestamp of 2013-03-22.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.19
AEROSPACI score: 0.49 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peptidyl-prolyl cis-trans isomerase FKBP4
    Species: Homo sapiens [TaxId:9606]
    Gene: FKBP4, FKBP52
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4drja_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase mTOR
    Species: Homo sapiens [TaxId:9606]
    Gene: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42345 (8-97)
      • expression tag (2-7)
    Domains in SCOPe 2.07: d4drjb1, d4drjb2
  • Heterogens: RAP, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4drjA (A:)
    gamgmtaeemkatesgaqsaplpmegvdispkqdegvlkvikregtgtempmigdrvfvh
    ytgwlldgtkfdssldrkdkfsfdlgkgevikawdiaiatmkvgevchitckpeyaygsa
    gsppkippnatlvfevelfefkge
    

    Sequence, based on observed residues (ATOM records): (download)
    >4drjA (A:)
    pmegvdispkqdegvlkvikregtgtempmigdrvfvhytgwlldgtkfdssldrkdkfs
    fdlgkgevikawdiaiatmkvgevchitckpeyaygsagsppkippnatlvfevelfefk
    g
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4drjB (B:)
    gamdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygr
    dlmeaqewcrkymksgnvkdltqawdlyyhvfrriskq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4drjB (B:)
    mdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdl
    meaqewcrkymksgnvkdltqawdlyyhvfrriskq