PDB entry 4drj
View 4drj on RCSB PDB site
Description: o-crystal structure of the PPIase domain of FKBP52, Rapamycin and the FRB fragment of mTOR
Class: Isomerase/Transferase
Keywords: Fk-506 binding domain, Hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, kinase, signalling, mammalian target of Rapamycin, immunosuppression, cancer, Isomerase-Transferase complex
Deposited on
2012-02-17, released
2013-02-06
The last revision prior to the SCOPe 2.06 freeze date was dated
2013-03-27, with a file datestamp of
2013-03-22.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.19
AEROSPACI score: 0.49
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Peptidyl-prolyl cis-trans isomerase FKBP4
Species: Homo sapiens [TaxId:9606]
Gene: FKBP4, FKBP52
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4drja_ - Chain 'B':
Compound: Serine/threonine-protein kinase mTOR
Species: Homo sapiens [TaxId:9606]
Gene: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.06: d4drjb1, d4drjb2 - Heterogens: RAP, SO4, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4drjA (A:)
gamgmtaeemkatesgaqsaplpmegvdispkqdegvlkvikregtgtempmigdrvfvh
ytgwlldgtkfdssldrkdkfsfdlgkgevikawdiaiatmkvgevchitckpeyaygsa
gsppkippnatlvfevelfefkge
Sequence, based on observed residues (ATOM records): (download)
>4drjA (A:)
pmegvdispkqdegvlkvikregtgtempmigdrvfvhytgwlldgtkfdssldrkdkfs
fdlgkgevikawdiaiatmkvgevchitckpeyaygsagsppkippnatlvfevelfefk
g
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4drjB (B:)
gamdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygr
dlmeaqewcrkymksgnvkdltqawdlyyhvfrriskq
Sequence, based on observed residues (ATOM records): (download)
>4drjB (B:)
mdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygrdl
meaqewcrkymksgnvkdltqawdlyyhvfrriskq