PDB entry 4dri

View 4dri on RCSB PDB site
Description: Co-crystal structure of the PPIase domain of FKBP51, Rapamycin and the FRB fragment of mTOR
Class: Isomerase/Transferase
Keywords: Fk-506 binding domain, Hsp90 cochaperone, immunophilin, peptidyl-prolyl isomerase, mammalian target of Rapamycin, kinase, signalling, immunosuppression, cancer, Isomerase-Transferase complex
Deposited on 2012-02-17, released 2013-02-06
The last revision prior to the SCOPe 2.07 freeze date was dated 2013-03-27, with a file datestamp of 2013-03-22.
Experiment type: XRAY
Resolution: 1.45 Å
R-factor: 0.178
AEROSPACI score: 0.67 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Peptidyl-prolyl cis-trans isomerase FKBP5
    Species: Homo sapiens [TaxId:9606]
    Gene: AIG6, FKBP5, FKBP51
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.07: d4dria_
  • Chain 'B':
    Compound: Serine/threonine-protein kinase mTOR
    Species: Homo sapiens [TaxId:9606]
    Gene: FRAP, FRAP1, FRAP2, MTOR, RAFT1, RAPT1
    Database cross-references and differences (RAF-indexed):
    • Uniprot P42345 (8-End)
      • expression tag (0-7)
    Domains in SCOPe 2.07: d4drib1, d4drib2
  • Heterogens: RAP, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4driA (A:)
    gamgmttdegaknneesptatvaeqgeditskkdrgvlkivkrvgngeetpmigdkvyvh
    ykgklsngkkfdsshdrnepfvfslgkgqvikawdigvatmkkgeichllckpeyaygsa
    gslpkipsnatlffeielldfkge
    

    Sequence, based on observed residues (ATOM records): (download)
    >4driA (A:)
    eqgeditskkdrgvlkivkrvgngeetpmigdkvyvhykgklsngkkfdsshdrnepfvf
    slgkgqvikawdigvatmkkgeichllckpeyaygsagslpkipsnatlffeielldfkg
    e
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4driB (B:)
    gamdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygr
    dlmeaqewcrkymksgnvkdltqawdlyyhvfrriskq
    

    Sequence, based on observed residues (ATOM records): (download)
    >4driB (B:)
    gamdpefmemwhegleeasrlyfgernvkgmfevleplhammergpqtlketsfnqaygr
    dlmeaqewcrkymksgnvkdltqawdlyyhvfrris