PDB entry 4do4
View 4do4 on RCSB PDB site
Description: Pharmacological chaperones for human alpha-N-acetylgalactosaminidase
Class: hydrolase/hydrolase inhibitor
Keywords: PHARMACOLOGICAL CHAPERONE, (BETA/ALPHA)8 BARREL, GLYCOSIDASE, CARBOHYDRATE-BINDING PROTEIN, GLYCOPROTEIN, LYSOSOME, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on
2012-02-09, released
2012-10-10
The last revision prior to the SCOPe 2.08 freeze date was dated
2020-07-29, with a file datestamp of
2020-07-04.
Experiment type: XRAY
Resolution: 1.4 Å
R-factor: N/A
AEROSPACI score: 0.61
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: alpha-N-acetylgalactosaminidase
Species: Homo sapiens [TaxId:9606]
Gene: nagA
Database cross-references and differences (RAF-indexed):
- Uniprot P17050 (0-End)
- engineered mutation (183)
Domains in SCOPe 2.08: d4do4a1, d4do4a2 - Chain 'B':
Compound: alpha-N-acetylgalactosaminidase
Species: Homo sapiens [TaxId:9606]
Gene: nagA
Database cross-references and differences (RAF-indexed):
- Uniprot P17050 (0-393)
- engineered mutation (183)
- expression tag (394-399)
Domains in SCOPe 2.08: d4do4b1, d4do4b2, d4do4b3 - Heterogens: NAG, DJN, CIT, GOL, ACY, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4do4A (A:)
ldngllqtppmgwlawerfrcnincdedpknciseqlfmemadrmaqdgwrdmgytylni
ddcwiggrdasgrlmpdpkrfphgipfladyvhslglklgiyadmgnftcmgypgttldk
vvqdaqtfaewkvdmlkldgcfstpeeraqgypkmaaalnatgrpiafscswpayegglp
prvqyslladicnlwrnyddiqdswwsvlsilnwfvehqdilqpvagpghwndpdmllig
nfglsleqsraqmalwtvlaapllmstdlrtisaqnmdilqnplmikinqdplgiqgrri
hkekslievymrplsnkasalvffscrtdmpyryhsslgqlnftgsviyeaqdvysgdii
sglrdetnftviinpsgvvmwylypiknlemsqqhhhhhh
Sequence, based on observed residues (ATOM records): (download)
>4do4A (A:)
ldngllqtppmgwlawerfrcnincdedpknciseqlfmemadrmaqdgwrdmgytylni
ddcwiggrdasgrlmpdpkrfphgipfladyvhslglklgiyadmgnftcmgypgttldk
vvqdaqtfaewkvdmlkldgcfstpeeraqgypkmaaalnatgrpiafscswpayegglp
prvqyslladicnlwrnyddiqdswwsvlsilnwfvehqdilqpvagpghwndpdmllig
nfglsleqsraqmalwtvlaapllmstdlrtisaqnmdilqnplmikinqdplgiqgrri
hkekslievymrplsnkasalvffscrtdmpyryhsslgqlnftgsviyeaqdvysgdii
sglrdetnftviinpsgvvmwylypik
- Chain 'B':
Sequence; same for both SEQRES and ATOM records: (download)
>4do4B (B:)
ldngllqtppmgwlawerfrcnincdedpknciseqlfmemadrmaqdgwrdmgytylni
ddcwiggrdasgrlmpdpkrfphgipfladyvhslglklgiyadmgnftcmgypgttldk
vvqdaqtfaewkvdmlkldgcfstpeeraqgypkmaaalnatgrpiafscswpayegglp
prvqyslladicnlwrnyddiqdswwsvlsilnwfvehqdilqpvagpghwndpdmllig
nfglsleqsraqmalwtvlaapllmstdlrtisaqnmdilqnplmikinqdplgiqgrri
hkekslievymrplsnkasalvffscrtdmpyryhsslgqlnftgsviyeaqdvysgdii
sglrdetnftviinpsgvvmwylypiknlemsqqhhhhhh