PDB entry 4dhy

View 4dhy on RCSB PDB site
Description: Crystal structure of human glucokinase in complex with glucose and activator
Class: transferase/transferase activator
Keywords: DIABETES MELLITUS, DISEASE MUTATION, GLYCOLYSIS, TRANSFERASE, TRANSFERASE-TRANSFERASE ACTIVATOR complex
Deposited on 2012-01-30, released 2012-02-08
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-05-09, with a file datestamp of 2012-05-04.
Experiment type: XRAY
Resolution: 2.38 Å
R-factor: 0.186
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucokinase
    Species: Homo sapiens [TaxId:9606]
    Gene: GCK
    Database cross-references and differences (RAF-indexed):
    • Uniprot P35557 (15-End)
      • expression tag (7-14)
    Domains in SCOPe 2.03: d4dhya1, d4dhya2
  • Heterogens: GLC, S41, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dhyA (A:)
mhhhhhhenlyfqgmkkekveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvk
mlptyvrstpegsevgdflsldlggtnfrvmlvkvgegeegqwsvktkhqmysipedamt
gtaemlfdyisecisdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasga
egnnvvgllrdaikrrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacyme
emqnvelvegdegrmcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggk
ymgelvrlvllrlvdenllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlg
lrpsttdcdivrracesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklh
psfkerfhasvrrltpsceitfieseegsgrgaalvsavackkacmlgq

    Sequence, based on observed residues (ATOM records): (download) 
    >4dhyA (A:)
enlyfqgmkkekveqilaefqlqeedlkkvmrrmqkemdrglrletheeasvkmlptyvr
stpegsevgdflsldlggtnfrvmlvkvgsvktkhqmysipedamtgtaemlfdyiseci
sdfldkhqmkhkklplgftfsfpvrhedidkgillnwtkgfkasgaegnnvvgllrdaik
rrgdfemdvvamvndtvatmiscyyedhqcevgmivgtgcnacymeemqnvelvegdegr
mcvntewgafgdsgeldeflleydrlvdessanpgqqlyekliggkymgelvrlvllrlv
denllfhgeaseqlrtrgafetrfvsqvesdtgdrkqiynilstlglrpsttdcdivrra
cesvstraahmcsaglagvinrmresrsedvmritvgvdgsvyklhpsfkerfhasvrrl
tpsceitfieseegsgrgaalvsavack