PDB entry 4dht

View 4dht on RCSB PDB site
Description: Small-molecule inhibitors of 14-3-3 protein-protein interactions from virtual screening
Class: protein binding/inhibitor
Keywords: HELICAL PROTEIN, ADAPTER PROTEIN, PHOSPHOPROTEIN BINDING, PROTEIN BINDING-INHIBITOR complex
Deposited on 2012-01-30, released 2013-07-31
The last revision prior to the SCOPe 2.08 freeze date was dated 2013-09-04, with a file datestamp of 2013-08-30.
Experiment type: XRAY
Resolution: 1.8 Å
R-factor: 0.164
AEROSPACI score: 0.57 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 14-3-3 protein sigma
    Species: Homo sapiens [TaxId:9606]
    Gene: HME1, SFN
    Database cross-references and differences (RAF-indexed):
    • Uniprot P31947 (4-234)
      • expression tag (0-3)
    Domains in SCOPe 2.08: d4dhta1, d4dhta2
  • Heterogens: MG, CL, GOL, 0KG, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dhtA (A:)
amgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggqr
aawrvlssieqksneegseekgpevreyrekvetelqgvcdtvlglldshlikeagdaes
rvfylkmkgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnf
svfhyeianspeeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwt

    Sequence, based on observed residues (ATOM records): (download) 
    >4dhtA (A:)
amgsmerasliqkaklaeqaeryedmaafmkgavekgeelsceernllsvayknvvggqr
aawrvlssieqksngpevreyrekvetelqgvcdtvlglldshlikeagdaesrvfylkm
kgdyyrylaevatgddkkriidsarsayqeamdiskkempptnpirlglalnfsvfhyei
anspeeaislakttfdeamadlhtlsedsykdstlimqllrdnltlwt