PDB entry 4dg1
View 4dg1 on RCSB PDB site
Description: Crystal structure of HIV-1 reverse transcriptase (RT) with polymorphism mutation K172A and K173A
Class: transferase
Keywords: Polymorphism 172K, P51/P66, HETERO DIMER, AIDS, HIV, RESISTANCE MUTATIONS, right-hand configuration, RNase H domain, Reverse transcriptase, ribonuclease H, RNA-DIRECTED DNA POLYMERASE, DNA POLYMERASE, TRANSFERASE, AZT excision, AZT unblocking, nevirapine, efavirenz, AZT, NUCLEOSIDE INHIBITORS, Nonnucleoside Inhibitors, NRTI, NNRTI
Deposited on
2012-01-24, released
2012-06-20
The last revision prior to the SCOPe 2.08 freeze date was dated
2012-09-12, with a file datestamp of
2012-09-07.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.232
AEROSPACI score: 0.36
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Reverse transcriptase P66 SUBUNIT
Species: Human immunodeficiency virus type 1 [TaxId:11678]
Database cross-references and differences (RAF-indexed):
- Uniprot P03366 (0-548)
- engineered mutation (171-172)
- engineered mutation (279)
Domains in SCOPe 2.08: d4dg1a1, d4dg1a2 - Chain 'B':
Compound: Reverse transcriptase P51 SUBUNIT
Species: Human immunodeficiency virus type 1 [TaxId:11678]
Database cross-references and differences (RAF-indexed):
- Uniprot P03366 (0-426)
- engineered mutation (279)
Domains in SCOPe 2.08: d4dg1b_ - Heterogens: MG, EDO, GOL, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence; same for both SEQRES and ATOM records: (download)
>4dg1A (A:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfaaqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwyqlekepivgaetfyvdgaanretklgkagyvtnkgrqkvvpltnttnqktelq
aiylalqdsglevnivtdsqyalgiiqaqpdkseselvnqiieqlikkekvylawvpahk
giggneqvd
- Chain 'B':
Sequence, based on SEQRES records: (download)
>4dg1B (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwglttpdkkhqkeppflwmgyelhpdkwt
vqpivlpekdswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeae
lelaenreilkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrga
htndvkqlteavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntp
plvklwy
Sequence, based on observed residues (ATOM records): (download)
>4dg1B (B:)
pispietvpvklkpgmdgpkvkqwplteekikalveictemekegkiskigpenpyntpv
faikkkdstkwrklvdfrelnkrtqdfwevqlgiphpaglkkkksvtvldvgdayfsvpl
dedfrkytaftipsinnetpgiryqynvlpqgwkgspaifqssmtkilepfkkqnpdivi
yqymddlyvgsdleigqhrtkieelrqhllrwgltppflwmgyelhpdkwtvqpivlpek
dswtvndiqklvgklnwasqiypgikvrqlskllrgtkalteviplteeaelelaenrei
lkepvhgvyydpskdliaeiqkqgqgqwtyqiyqepfknlktgkyarmrgahtndvkqlt
eavqkittesiviwgktpkfklpiqketwetwwteywqatwipewefvntpplvklwy