PDB entry 4dem
View 4dem on RCSB PDB site
Description: Crystal structure of human FPPS in complex with YS_04_70
Class: transferase/transferase inhibitor
Keywords: MEVALONATE PATHWAY, ISOPRENE BIOSYNTHESIS, CHOLESTEROL BIOSYNTHESIS, BISPHOSPHONATE, TRANSFERASE, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-01-20, released
2012-03-21
The last revision prior to the SCOPe 2.04 freeze date was dated
2012-04-25, with a file datestamp of
2012-04-20.
Experiment type: XRAY
Resolution: 1.85 Å
R-factor: 0.175
AEROSPACI score: 0.54
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'F':
Compound: farnesyl pyrophosphate synthase
Species: Homo sapiens [TaxId:9606]
Gene: FDPS, FPS, KIAA1293
Database cross-references and differences (RAF-indexed):
Domains in SCOPe 2.04: d4demf_ - Heterogens: YS4, MG, HOH
PDB Chain Sequences:
- Chain 'F':
Sequence, based on SEQRES records: (download)
>4demF (F:)
mgsshhhhhhssgrenlyfqghmngdqnsdvyaqekqdfvqhfsqivrvltedemghpei
gdaiarlkevleynaiggkynrgltvvvafrelveprkqdadslqrawtvgwcvellqaf
flvaddimdssltrrgqicwyqkpgvgldaindanlleaciyrllklycreqpyylnlie
lflqssyqteigqtldlltapqgnvdlvrftekryksivkyktafysfylpiaaamymag
idgekehanakkillemgeffqiqddyldlfgdpsvtgkigtdiqdnkcswlvvqclqra
tpeqyqilkenygqkeaekvarvkalyeeldlpavflqyeedsyshimalieqyaaplpp
avflglarkiykrrk
Sequence, based on observed residues (ATOM records): (download)
>4demF (F:)
dvyaqekqdfvqhfsqivrvltedemghpeigdaiarlkevleynaiggkynrgltvvva
frelveprkqdadslqrawtvgwcvellqafflvaddimdssltrrgqicwyqkpgvgld
aindanlleaciyrllklycreqpyylnlielflqssyqteigqtldlltapqgnvdlvr
ftekryksivkyktafysfylpiaaamymagidgekehanakkillemgeffqiqddyld
lfgdpsvtgkigtdiqdnkcswlvvqclqratpeqyqilkenygqkeaekvarvkalyee
ldlpavflqyeedsyshimalieqyaaplppavflglarkiykrrk