PDB entry 4deb

View 4deb on RCSB PDB site
Description: Aurora A in complex with RK2-17-01
Class: transferase/transferase inhibitor
Keywords: PROTEIN KINASE, AURORA A, INHIBITOR, DFG-IN, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on 2012-01-20, released 2012-08-22
The last revision prior to the SCOPe 2.05 freeze date was dated 2012-09-26, with a file datestamp of 2012-09-21.
Experiment type: XRAY
Resolution: 3.05 Å
R-factor: 0.224
AEROSPACI score: 0.23 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Aurora kinase A
    Species: Homo sapiens [TaxId:9606]
    Gene: AURKA, AIK, AIRK1, ARK1, AURA, AYK1, BTAK, IAK1, STK15, STK6
    Database cross-references and differences (RAF-indexed):
    • Uniprot O14965
      • engineered mutation (164)
    Domains in SCOPe 2.05: d4deba_
  • Heterogens: NHJ, EDO, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4debA (A:)
skkrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrrev
eiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelan
alsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrdtlcgtldylppemie
grmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisr
llkhnpsqrpmlrevlehpwitansskpsncqnkesask

    Sequence, based on observed residues (ATOM records): (download) 
    >4debA (A:)
krqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrrevei
qshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelanal
sychskrvihrdikpenlllgsagelkiadfgwsvhapssrrdtlcgtldylppemiegr
mhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrll
khnpsqrpmlrevlehpwitanss