PDB entry 4dea
View 4dea on RCSB PDB site
Description: Aurora A in complex with YL1-038-18
Class: transferase/transferase inhibitor
Keywords: PROTEIN KINASE, AURORA A, INHIBITOR, DFG-IN, TRANSFERASE-TRANSFERASE INHIBITOR complex
Deposited on
2012-01-20, released
2012-08-22
The last revision prior to the SCOPe 2.08 freeze date was dated
2012-09-26, with a file datestamp of
2012-09-21.
Experiment type: XRAY
Resolution: 2.45 Å
R-factor: 0.218
AEROSPACI score: 0.33
(click here for full SPACI score report)
Chains and heterogens:
- Chain 'A':
Compound: Aurora kinase A
Species: Homo sapiens [TaxId:9606]
Gene: AIK, AIRK1, ARK1, AURA, AURKA, AYK1, BTAK, IAK1, STK15, STK6
Database cross-references and differences (RAF-indexed):
- Uniprot O14965
- engineered mutation (164)
Domains in SCOPe 2.08: d4deaa_ - Heterogens: EDO, NHI, HOH
PDB Chain Sequences:
- Chain 'A':
Sequence, based on SEQRES records: (download)
>4deaA (A:)
skkrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrrev
eiqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelan
alsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrdtlcgtldylppemie
grmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisr
llkhnpsqrpmlrevlehpwitansskpsncqnkesask
Sequence, based on observed residues (ATOM records): (download)
>4deaA (A:)
kkrqwaledfeigrplgkgkfgnvylarekqskfilalkvlfkaqlekagvehqlrreve
iqshlrhpnilrlygyfhdatrvylileyaplgtvyrelqklskfdeqrtatyitelana
lsychskrvihrdikpenlllgsagelkiadfgwsvhapssrrdtlcgtldylppemieg
rmhdekvdlwslgvlcyeflvgkppfeantyqetykrisrveftfpdfvtegardlisrl
lkhnpsqrpmlrevlehpwitanssk