PDB entry 4dd8

View 4dd8 on RCSB PDB site
Description: ADAM-8 metalloproteinase domain with bound batimastat
Class: hydrolase/hydrolase inhibitor
Keywords: batimastat, inflammation, alpha/beta motif, metalloproteinase, allergic asthma, tumorigenesis, arthritis, aberrant neural cell signaling, HYDROLASE-HYDROLASE INHIBITOR complex
Deposited on 2012-01-18, released 2012-06-06
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-06-27, with a file datestamp of 2012-06-22.
Experiment type: XRAY
Resolution: 2.1 Å
R-factor: 0.192
AEROSPACI score: 0.42 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Disintegrin and metalloproteinase domain-containing protein 8
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM8, MS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4dd8a_
  • Chain 'B':
    Compound: Disintegrin and metalloproteinase domain-containing protein 8
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM8, MS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4dd8b_
  • Chain 'C':
    Compound: Disintegrin and metalloproteinase domain-containing protein 8
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM8, MS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4dd8c_
  • Chain 'D':
    Compound: Disintegrin and metalloproteinase domain-containing protein 8
    Species: Homo sapiens [TaxId:9606]
    Gene: ADAM8, MS2
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.03: d4dd8d_
  • Heterogens: BAT, CA, ZN, NA, CL, K, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dd8A (A:)
sretryvelyvvvdnaefqmlgseaavrhrvlevvnhvdklyqklnfrvvlvgleiwnsq
drfhvspdpsvtlenlltwqarqrtrrhlhdnvqlitgvdftgttvgfarvsamcshssg
avnqdhsknpvgvactmahemghnlgmdhdenvqgcrcqerfeagrcimagsigssfprm
fsdcsqaylesflerpqsvclanapdls

    Sequence, based on observed residues (ATOM records): (download) 
    >4dd8A (A:)
retryvelyvvvdnaefqmlgseaavrhrvlevvnhvdklyqklnfrvvlvgleiwnsqd
rfhvspdpsvtlenlltwqarrhlhdnvqlitgvdftgttvgfarvsamcshssgavnqd
hsknpvgvactmahemghnlgmdhdenvqgcrcqerfeagrcimagsigssfprmfsdcs
qaylesflerpqsvclanapd

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4dd8B (B:)
sretryvelyvvvdnaefqmlgseaavrhrvlevvnhvdklyqklnfrvvlvgleiwnsq
drfhvspdpsvtlenlltwqarqrtrrhlhdnvqlitgvdftgttvgfarvsamcshssg
avnqdhsknpvgvactmahemghnlgmdhdenvqgcrcqerfeagrcimagsigssfprm
fsdcsqaylesflerpqsvclanapdls

    Sequence, based on observed residues (ATOM records): (download) 
    >4dd8B (B:)
retryvelyvvvdnaefqmlgseaavrhrvlevvnhvdklyqklnfrvvlvgleiwnsqd
rfhvspdpsvtlenlltwqarqrtrrhlhdnvqlitgvdftgttvgfarvsamcshssga
vnqdhsknpvgvactmahemghnlgmdhdenvqgcrcqerfeagrcimagsigssfprmf
sdcsqaylesflerpqsvclanapd

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4dd8C (C:)
sretryvelyvvvdnaefqmlgseaavrhrvlevvnhvdklyqklnfrvvlvgleiwnsq
drfhvspdpsvtlenlltwqarqrtrrhlhdnvqlitgvdftgttvgfarvsamcshssg
avnqdhsknpvgvactmahemghnlgmdhdenvqgcrcqerfeagrcimagsigssfprm
fsdcsqaylesflerpqsvclanapdls

    Sequence, based on observed residues (ATOM records): (download) 
    >4dd8C (C:)
retryvelyvvvdnaefqmlgseaavrhrvlevvnhvdklyqklnfrvvlvgleiwnsqd
rfhvspdpsvtlenlltwqarqrhlhdnvqlitgvdftgttvgfarvsamcshssgavnq
dhsknpvgvactmahemghnlgmdhdenvqgcrcqerfeagrcimagsigssfprmfsdc
sqaylesflerpqsvclanap

  • Chain 'D':
    Sequence; same for both SEQRES and ATOM records: (download) 
    >4dd8D (D:)
sretryvelyvvvdnaefqmlgseaavrhrvlevvnhvdklyqklnfrvvlvgleiwnsq
drfhvspdpsvtlenlltwqarqrtrrhlhdnvqlitgvdftgttvgfarvsamcshssg
avnqdhsknpvgvactmahemghnlgmdhdenvqgcrcqerfeagrcimagsigssfprm
fsdcsqaylesflerpqsvclanapdls