PDB entry 4dce

View 4dce on RCSB PDB site
Description: Crystal structure of human anaplastic lymphoma kinase in complex with a piperidine-carboxamide inhibitor
Class: Transferase/Inhibitor
Keywords: receptor tyrosine kinase, inhibitor, NPM-ALK, EML4-ALK, Transferase-Inhibitor complex
Deposited on 2012-01-17, released 2012-02-08
The last revision prior to the SCOPe 2.03 freeze date was dated 2012-05-09, with a file datestamp of 2012-05-04.
Experiment type: XRAY
Resolution: 2.03 Å
R-factor: 0.211
AEROSPACI score: 0.43 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered mutation (19)
    Domains in SCOPe 2.03: d4dcea_
  • Chain 'B':
    Compound: ALK tyrosine kinase receptor
    Species: Homo sapiens [TaxId:9606]
    Gene: ALK
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q9UM73
      • engineered mutation (19)
    Domains in SCOPe 2.03: d4dceb_
  • Heterogens: 0JF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4dceA (A:)
yklsklrtstimtdynpnysfagktssisdlkevprknitlirglghgafgevyegqvsg
mpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfille
lmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarncll
tcpgpgrvakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgv
llweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfa
iilerieyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >4dceA (A:)
npnysfagktssisdlkevprknitlirglghgevyegqvspsplqvavktlpevcseqd
eldflmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpss
lamldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfggcamlpvk
wmppeafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppknc
pgpvyrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4dceB (B:)
yklsklrtstimtdynpnysfagktssisdlkevprknitlirglghgafgevyegqvsg
mpndpsplqvavktlpevcseqdeldflmealiiskfnhqnivrcigvslqslprfille
lmaggdlksflretrprpsqpsslamldllhvardiacgcqyleenhfihrdiaarncll
tcpgpgrvakigdfgmardiyrasyyrkggcamlpvkwmppeafmegiftsktdtwsfgv
llweifslgympypsksnqevlefvtsggrmdppkncpgpvyrimtqcwqhqpedrpnfa
iilerieyctqdpdvintalpieygplveeeek

    Sequence, based on observed residues (ATOM records): (download) 
    >4dceB (B:)
pnysfagktssisdlkevprknitlirglghevyegqvssplqvavktlpevcseqdeld
flmealiiskfnhqnivrcigvslqslprfillelmaggdlksflretrprpsqpsslam
ldllhvardiacgcqyleenhfihrdiaarnclltcpgpgrvakigdfgcamlpvkwmpp
eafmegiftsktdtwsfgvllweifslgympypsksnqevlefvtsggrmdppkncpgpv
yrimtqcwqhqpedrpnfaiilerieyctqdpdvintalpieyg