PDB entry 4da5

View 4da5 on RCSB PDB site
Description: Choline Kinase alpha acts through a double-displacement kinetic mechanism involving enzyme isomerisation, as determined through enzyme and inhibitor kinetics and structural biology
Class: Transferase/Transferase Inhibitor
Keywords: kinase, signal transduction, cytoplasmic, Transferase-Transferase Inhibitor complex
Deposited on 2012-01-12, released 2013-04-17
The last revision prior to the SCOPe 2.08 freeze date was dated 2016-06-22, with a file datestamp of 2016-06-17.
Experiment type: XRAY
Resolution: 2.4 Å
R-factor: N/A
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: choline kinase alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CHKA, CHK, CKI
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4da5a_
  • Chain 'B':
    Compound: choline kinase alpha
    Species: Homo sapiens [TaxId:9606]
    Gene: CHKA, CHK, CKI
    Database cross-references and differences (RAF-indexed): Domains in SCOPe 2.08: d4da5b_
  • Heterogens: SO4, 0H7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4da5A (A:)
mktkfctggeaepsplglllscgsgsaapapgvgqqrdaasdleskqlggqqpplalppp
pplplplplpqppppqppadeqpeprtrrraylwckeflpgawrglredefhisvirggl
snmlfqcslpdttatlgdeprkvllrlygailqmrscnkegseqaqkenefqgaeamvle
svmfailaerslgpklygifpqgrleqfipsrrldteelslpdisaeiaekmatfhgmkm
pfnkepkwlfgtmekylkevlrikfteesrikklhkllsynlplelenlrsllestpspv
vfchndcqegnilllegrensekqklmlidfeyssynyrgfdignhfcewmydysyekyp
ffranirkyptkkqqlhfissylpafqndfenlsteeksiikeemllevnrfalashflw
glwsivqakissiefgymdyaqarfdayfhqkrklgv

    Sequence, based on observed residues (ATOM records): (download) 
    >4da5A (A:)
eqpeprtrrraylwckeflpgawrglredefhisvirgglsnmlfqcslpdttatlgdep
rkvllrlyaeamvlesvmfailaerslgpklygifpqgrleqfipsrrldteelslpdis
aeiaekmatfhgmkmpfnkepkwlfgtmekylkevlrikfteesrikklhkllsynlple
lenlrsllestpspvvfchndcqegnilllegrensekqklmlidfeyssynyrgfdign
hfcewmydysyekypffranirkyptkkqqlhfissylpafqndfenlsteeksiikeem
llevnrfalashflwglwsivqakissiefgymdyaqarfdayfhqkrklgv

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4da5B (B:)
mktkfctggeaepsplglllscgsgsaapapgvgqqrdaasdleskqlggqqpplalppp
pplplplplpqppppqppadeqpeprtrrraylwckeflpgawrglredefhisvirggl
snmlfqcslpdttatlgdeprkvllrlygailqmrscnkegseqaqkenefqgaeamvle
svmfailaerslgpklygifpqgrleqfipsrrldteelslpdisaeiaekmatfhgmkm
pfnkepkwlfgtmekylkevlrikfteesrikklhkllsynlplelenlrsllestpspv
vfchndcqegnilllegrensekqklmlidfeyssynyrgfdignhfcewmydysyekyp
ffranirkyptkkqqlhfissylpafqndfenlsteeksiikeemllevnrfalashflw
glwsivqakissiefgymdyaqarfdayfhqkrklgv

    Sequence, based on observed residues (ATOM records): (download) 
    >4da5B (B:)
raylwckeflpgawrglhisvlfqcslpdttatlgdeprkvllrlygeamvlesvmfail
aerslgpklygifpqgrleqfipsrrldteelslpdisaeiaekmatfhgmkmpfnkepk
wlfgtmekylkevlrikfteesrikklhkllsynlplelenlrsllestpspvvfchndc
qegnilllegrensekqklmlidfeyssynyrgfdignhfcewmydysyekypffranir
kyptkkqqlhfissylpafqndfenlsteeksiikeemllevnrfalashflwglwsivq
akissiefgymdyaqarfdayfhqkrklgv