PDB entry 4d2p

View 4d2p on RCSB PDB site
Description: Structure of MELK in complex with inhibitors
Class: transferase
Keywords: transferase, fragment sterbased drug design, kinase
Deposited on 2014-05-12, released 2014-10-08
The last revision prior to the SCOPe 2.08 freeze date was dated 2018-04-04, with a file datestamp of 2018-03-29.
Experiment type: XRAY
Resolution: 2.55 Å
R-factor: N/A
AEROSPACI score: 0.19 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: maternal embryonic leucine zipper kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14680 (20-End)
      • engineered mutation (190)
      • engineered mutation (232-234)
      • engineered mutation (237-238)
    Domains in SCOPe 2.08: d4d2pa_
  • Chain 'B':
    Compound: maternal embryonic leucine zipper kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14680 (20-End)
      • engineered mutation (190)
      • engineered mutation (232-234)
      • engineered mutation (237-238)
    Domains in SCOPe 2.08: d4d2pb_
  • Chain 'C':
    Compound: maternal embryonic leucine zipper kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14680 (20-End)
      • expression tag (19)
      • engineered mutation (190)
      • engineered mutation (232-234)
      • engineered mutation (237-238)
    Domains in SCOPe 2.08: d4d2pc1, d4d2pc2
  • Chain 'D':
    Compound: maternal embryonic leucine zipper kinase
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot Q14680 (20-End)
      • engineered mutation (190)
      • engineered mutation (232-234)
      • engineered mutation (237-238)
    Domains in SCOPe 2.08: d4d2pd_
  • Heterogens: 6Z7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4d2pA (A:)
mgsshhhhhhssglvprgshmkdydellkyyelhetigtggfakvklachiltgemvaik
imdkntlgsdlprikteiealknlrhqhicqlyhvletankifmvleycpggelfdyiis
qdrlseeetrvvfrqivsavayvhsqgyahrdlkpenllfdeyhklklidfglcakpkgn
kdyhlqaccgalayaapeliqgksylgseadvwsmgillyvlmcgflpfdddtaaalvak
imrgkydvpkwlspssilllqqmlqvdpkkrismknllnhpwimqdynypvewqsknpfi
hldddcvtelsvhhrnnrqtmedlislwqydhltatyllllakkargkpvrlrlss

    Sequence, based on observed residues (ATOM records): (download) 
    >4d2pA (A:)
mkdydellkyyelhetigtggfakvklachiltgemvaikimdkntdlprikteiealkn
lrhqhicqlyhvletankifmvleycpggelfdyiisqdrlseeetrvvfrqivsavayv
hsqgyahrdlkpenllfdeyhklklidfglcagalayaapeliqgkgseadvwsmgilly
vlmcgflpfdddtaaalvakimrgkydvpkwlspssilllqqmlqvdpkkrismknllnh
pwimqdynypvewqsknpfihldddcvtelsvhhrnnrqtmedlislwqydhltatylll
lakkargkpvrlr

  • Chain 'B':
    Sequence, based on SEQRES records: (download) 
    >4d2pB (B:)
mgsshhhhhhssglvprgshmkdydellkyyelhetigtggfakvklachiltgemvaik
imdkntlgsdlprikteiealknlrhqhicqlyhvletankifmvleycpggelfdyiis
qdrlseeetrvvfrqivsavayvhsqgyahrdlkpenllfdeyhklklidfglcakpkgn
kdyhlqaccgalayaapeliqgksylgseadvwsmgillyvlmcgflpfdddtaaalvak
imrgkydvpkwlspssilllqqmlqvdpkkrismknllnhpwimqdynypvewqsknpfi
hldddcvtelsvhhrnnrqtmedlislwqydhltatyllllakkargkpvrlrlss

    Sequence, based on observed residues (ATOM records): (download) 
    >4d2pB (B:)
mkdydellkyyelhetigtggfakvklachiltgemvaikimdkntlgsdlprikteiea
lknlrhqhicqlyhvletankifmvleycpggelfdyiisqdrlseeetrvvfrqivsav
ayvhsqgyahrdlkpenllfdeyhklklidfglcakpkgnkdcgalayaapeliqggsea
dvwsmgillyvlmcgflpfdddtaaalvakimrgkydvpkwlspssilllqqmlqvdpkk
rismknllnhpwimqdynypvewqsknpfihldddcvtelsvhhrnnrqtmedlislwqy
dhltatyllllakkargkpvrlr

  • Chain 'C':
    Sequence, based on SEQRES records: (download) 
    >4d2pC (C:)
mgsshhhhhhssglvprgshmkdydellkyyelhetigtggfakvklachiltgemvaik
imdkntlgsdlprikteiealknlrhqhicqlyhvletankifmvleycpggelfdyiis
qdrlseeetrvvfrqivsavayvhsqgyahrdlkpenllfdeyhklklidfglcakpkgn
kdyhlqaccgalayaapeliqgksylgseadvwsmgillyvlmcgflpfdddtaaalvak
imrgkydvpkwlspssilllqqmlqvdpkkrismknllnhpwimqdynypvewqsknpfi
hldddcvtelsvhhrnnrqtmedlislwqydhltatyllllakkargkpvrlrlss

    Sequence, based on observed residues (ATOM records): (download) 
    >4d2pC (C:)
hmkdydellkyyelhetigtggfakvklachiltgemvaikimdknsdlprikteiealk
nlrhqhicqlyhvletankifmvleycpggelfdyiisqdrlseeetrvvfrqivsavay
vhsqgyahrdlkpenllfdeyhklklidfglcakgalayaapeliqgksgseadvwsmgi
llyvlmcgflpfdddtaaalvakimrgkydvpkwlspssilllqqmlqvdpkkrismknl
lnhpwimqdynypvewqsknpfihldddcvtelsvhhrnnrqtmedlislwqydhltaty
llllakkargkpvrlr

  • Chain 'D':
    Sequence, based on SEQRES records: (download) 
    >4d2pD (D:)
mgsshhhhhhssglvprgshmkdydellkyyelhetigtggfakvklachiltgemvaik
imdkntlgsdlprikteiealknlrhqhicqlyhvletankifmvleycpggelfdyiis
qdrlseeetrvvfrqivsavayvhsqgyahrdlkpenllfdeyhklklidfglcakpkgn
kdyhlqaccgalayaapeliqgksylgseadvwsmgillyvlmcgflpfdddtaaalvak
imrgkydvpkwlspssilllqqmlqvdpkkrismknllnhpwimqdynypvewqsknpfi
hldddcvtelsvhhrnnrqtmedlislwqydhltatyllllakkargkpvrlrlss

    Sequence, based on observed residues (ATOM records): (download) 
    >4d2pD (D:)
mkdydellkyyelhetigtggfakvklachiltgemvaikimdkntlgsdlprikteiea
lknlrhqhicqlyhvletankifmvleycpggelfdyiisqdrlseeetrvvfrqivsav
ayvhsqgyahrdlkpenllfdeyhklklidfglcakpkgnkdgalayaapeliqgksylg
seadvwsmgillyvlmcgflpfdddtaaalvakimrgkydvpkwlspssilllqqmlqvd
pkkrismknllnhpwimqdynypvewqskfihlddvtelsvhhrnnrqislwqydhltat
yllllakkargkpvrlr