PDB entry 4cx0

View 4cx0 on RCSB PDB site
Description: Structure of bovine endothelial nitric oxide synthase Y477A mutant heme domain in complex with 6-((((3S, 5R)-5-(((6-AMINO-4- METHYLPYRIDIN-2-YL)METHOXY)METHYL)PYRROLIDIN-3-YL)OXY)METHYL)-4- METHYLPYRIDIN-2-AMINE
Class: oxidoreductase
Keywords: oxidoreductase, inhibitor complex
Deposited on 2014-04-03, released 2014-08-13
The last revision prior to the SCOPe 2.07 freeze date was dated 2014-09-03, with a file datestamp of 2014-08-29.
Experiment type: XRAY
Resolution: 2.2 Å
R-factor: 0.15711
AEROSPACI score: 0.36 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Nitric oxide synthase, endothelial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29473 (Start-442)
      • see remark 999 (60)
      • engineered mutation (437)
    Domains in SCOPe 2.07: d4cx0a_
  • Chain 'B':
    Compound: Nitric oxide synthase, endothelial
    Species: Bos taurus [TaxId:9913]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P29473 (Start-442)
      • see remark 999 (60)
      • engineered mutation (437)
    Domains in SCOPe 2.07: d4cx0b_
  • Heterogens: HEM, H4B, Q16, ACT, GOL, ZN, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download)
    >4cx0A (A:)
    rapapatphapdhspapnsptltrppegpkfprvknwelgsitydtlcaqsqqdgpctpr
    rclgslvlprklqtrpspgpppaeqllsqardfinqyyssikrsgsqaheerlqeveaev
    astgtyhlreselvfgakqawrnaprcvgriqwgklqvfdardcssaqemftyicnhiky
    atnrgnlrsaitvfpqrapgrgdfriwnsqlvryagyrqqdgsvrgdpanveitelciqh
    gwtpgngrfdvlplllqapdeapelfvlppelvlevplehptlewfaalglrwyalpavs
    nmlleigglefsaapfsgwymsteigtrnlcdphryniledvavcmdldtrttsslwkdk
    aaveinlavlhsfqlakvtivdhhaatvsfmkhldneqkarggcpadwawivppisgslt
    pvfhqemvnyilspafraqpdpw
    

    Sequence, based on observed residues (ATOM records): (download)
    >4cx0A (A:)
    gpkfprvknwelgsitydtlcaqsqqdgpctprrclgslvlprpaeqllsqardfinqyy
    ssikrsgsqaheerlqeveaevastgtyhlreselvfgakqawrnaprcvgriqwgklqv
    fdardcssaqemftyicnhikyatnrgnlrsaitvfpqrapgrgdfriwnsqlvryagyr
    qqdgsvrgdpanveitelciqhgwtpgngrfdvlplllqapdeapelfvlppelvlevpl
    ehptlewfaalglrwyalpavsnmlleigglefsaapfsgwymsteigtrnlcdphryni
    ledvavcmdldtrttsslwkdkaaveinlavlhsfqlakvtivdhhaatvsfmkhldneq
    karggcpadwawivppisgsltpvfhqemvnyilspafraqpdpw
    

  • Chain 'B':
    Sequence, based on SEQRES records: (download)
    >4cx0B (B:)
    rapapatphapdhspapnsptltrppegpkfprvknwelgsitydtlcaqsqqdgpctpr
    rclgslvlprklqtrpspgpppaeqllsqardfinqyyssikrsgsqaheerlqeveaev
    astgtyhlreselvfgakqawrnaprcvgriqwgklqvfdardcssaqemftyicnhiky
    atnrgnlrsaitvfpqrapgrgdfriwnsqlvryagyrqqdgsvrgdpanveitelciqh
    gwtpgngrfdvlplllqapdeapelfvlppelvlevplehptlewfaalglrwyalpavs
    nmlleigglefsaapfsgwymsteigtrnlcdphryniledvavcmdldtrttsslwkdk
    aaveinlavlhsfqlakvtivdhhaatvsfmkhldneqkarggcpadwawivppisgslt
    pvfhqemvnyilspafraqpdpw
    

    Sequence, based on observed residues (ATOM records): (download)
    >4cx0B (B:)
    kfprvknwelgsitydtlcaqsqqdgpctprrclgslvlprpaeqllsqardfinqyyss
    ikrsgsqaheerlqeveaevastgtyhlreselvfgakqawrnaprcvgriqwgklqvfd
    ardcssaqemftyicnhikyatnrgnlrsaitvfpqrapgrgdfriwnsqlvryagyrqq
    dgsvrgdpanveitelciqhgwtpgngrfdvlplllqapdeapelfvlppelvlevpleh
    ptlewfaalglrwyalpavsnmlleigglefsaapfsgwymsteigtrnlcdphrynile
    dvavcmdldtrttsslwkdkaaveinlavlhsfqlakvtivdhhaatvsfmkhldneqka
    rggcpadwawivppisgsltpvfhqemvnyilspafraqpdpw