PDB entry 4cth

View 4cth on RCSB PDB site
Description: Neprilysin variant G399V,G714K in complex with phosphoramidon
Class: transferase
Keywords: transferase, amyloid beta, alzheimer's disease, enzyme engineering
Deposited on 2014-03-13, released 2014-08-13
The last revision prior to the SCOPe 2.06 freeze date was dated 2014-08-13, with a file datestamp of 2014-08-08.
Experiment type: XRAY
Resolution: 2.15 Å
R-factor: 0.2122
AEROSPACI score: 0.31 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Neprilysin
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P08473 (Start-708)
      • engineered mutation (358)
      • engineered mutation (673)
    Domains in SCOPe 2.06: d4ctha_
  • Heterogens: NAG, ZN, GOL, RDF, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4cthA (A:)
hhhhhhhhhhyddgickssdciksaarliqnmdattepctdffkyacggwlkrnvipets
srygnfdilrdelevvlkdvlqepktedivavqkakalyrscinesaidsrggepllkll
pdiygwpvatenweqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidq
prlglpsrdyyectgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelek
eianatakpedrndpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitne
edvvvyapeyltklkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalyvt
tsetatwrrcanyvngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwm
daetkkraeekalaikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqsk
qlkklrekvdkdewisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmv
igheithgfddngrnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlng
intlgeniadngglgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpe
yavnsiktdvhspknfriigtlqnsaefseafhcrknsymnpekkcrvw

    Sequence, based on observed residues (ATOM records): (download) 
    >4cthA (A:)
dgickssdciksaarliqnmdattepctdffkyacggwlkrnvipetssrygnfdilrde
levvlkdvlqepktedivavqkakalyrscinesaidsrggepllkllpdiygwpvaten
weqkygaswtaekaiaqlnskygkkvlinlfvgtddknsvnhvihidqprlglpsrdyye
ctgiykeactayvdfmisvarlirqeerlpidenqlalemnkvmelekeianatakpedr
ndpmllynkmtlaqiqnnfsleingkpfswlnftneimstvnisitneedvvvyapeylt
klkpiltkysardlqnlmswrfimdlvsslsrtykesrnafrkalyvttsetatwrrcan
yvngnmenavgrlyveaafageskhvvedliaqirevfiqtlddltwmdaetkkraeeka
laikerigypddivsndnklnneylelnykedeyfeniiqnlkfsqskqlkklrekvdkd
ewisgaavvnafyssgrnqivfpagilqppffsaqqsnslnyggigmvigheithgfddn
grnfnkdgdlvdwwtqqsasnfkeqsqcmvyqygnfswdlaggqhlngintlgeniadng
glgqayrayqnyikkngeekllpgldlnhkqlfflnfaqvwcgtyrpeyavnsiktdvhs
pknfriigtlqnsaefseafhcrknsymnpekkcrvw