PDB entry 4ct2

View 4ct2 on RCSB PDB site
Description: Human PDK1-PKCzeta Kinase Chimera
Class: transferase
Keywords: transferase, allosteric regulation, allosteric site, phosphorylation, agc protein kinase, chimeric protein
Deposited on 2014-03-11, released 2014-05-28
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-07-02, with a file datestamp of 2014-06-27.
Experiment type: XRAY
Resolution: 1.25 Å
R-factor: 0.1939
AEROSPACI score: 0.68 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: 3-phosphoinositide-dependent protein kinase 1
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot O15530 (Start-310)
      • engineered mutation (64)
      • engineered mutation (69)
      • engineered mutation (75)
      • engineered mutation (79)
      • engineered mutation (82)
      • engineered mutation (99)
      • engineered mutation (108)
      • engineered mutation (239)
      • engineered mutation (243)
    Domains in SCOPe 2.08: d4ct2a_
  • Heterogens: ATP, DTD, NA, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4ct2A (A:)
gamdgtaaeprpgagslqhaqpppqprkkrpedfkfgkilgegsfstvvlarelatsrey
aikivekrhvhkenkipyvqrekdvmsrldhpffvklyfcfqddeklylglsyakngell
kyirkigsfdetctrfytaeivsaleylhgkgiihrdlkpenillnedmhiqitdfgtak
vlspeskqaransfvgtaqyvspellteksackssdlwalgciiyqlvaglppfragneg
lifakiikleydfpekffpkardlvekllvldatkrlgceemegygplkahpffesvtwe
nlhqqtppklt

    Sequence, based on observed residues (ATOM records): (download) 
    >4ct2A (A:)
rkkrpedfkfgkilgegsfstvvlarelatsreyaikivekrhvipyvqrekdvmsrldh
pffvklyfcfqddeklylglsyakngellkyirkigsfdetctrfytaeivsaleylhgk
giihrdlkpenillnedmhiqitdfgtakvlspeskqaransfvgtaqyvspellteksa
ckssdlwalgciiyqlvaglppfragneglifakiikleydfpekffpkardlvekllvl
datkrlgceemegygplkahpffesvtwenlhqqtppklt