PDB entry 4csj

View 4csj on RCSB PDB site
Description: The discovery of potent selective glucocorticoid receptor modulators, suitable for inhalation
Class: signaling protein
Keywords: signaling protein, nuclear hormone receptor, ligand complex, peptide complex
Deposited on 2014-03-07, released 2014-05-07
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-05-21, with a file datestamp of 2014-05-16.
Experiment type: XRAY
Resolution: 2.3 Å
R-factor: 0.2193
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Glucocorticoid receptor
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P04150
      • engineered mutation (73)
      • engineered mutation (104)
      • engineered mutation (140)
    Domains in SCOPe 2.08: d4csja_
  • Chain 'B':
    Compound: nuclear receptor coactivator 2
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
  • Heterogens: EDO, NN7, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4csjA (A:)
gsiqqattgvsqetsenpgdktivpatlpqltptlvslleviepevlyagydssvpdstw
rimttlnmlggrqmiaavkwakaipgfrnlhlddqmtllqyswmslmafalgwrsyrqss
anllcfapdliineqrmtlpdmydqckhmlyvsselhrlqvsyeeylcmktllllssvpk
dglksqelfdeirmtyikelgkaivkregnssqnwqrfyqltklldsmhevvenllnycf
qtfldktmsiefpemlaeiitnqipkysngnikkllfhqk

    Sequence, based on observed residues (ATOM records): (download) 
    >4csjA (A:)
ptlvslleviepevlyagydssvpdstwrimttlnmlggrqmiaavkwakaipgfrnlhl
ddqmtllqyswmslmafalgwrsyrqssanllcfapdliineqrmtlpdmydqckhmlyv
sselhrlqvsyeeylcmktllllssvpkdglksqelfdeirmtyikelgkaivkregnss
qnwqrfyqltklldsmhevvenllnycfqtfldktmsiefpemlaeiitnqipkysngni
kkllfhq

  • Chain 'B':
    No sequence available.