PDB entry 4crg

View 4crg on RCSB PDB site
Description: Creating novel F1 inhibitors through fragment based lead generation and structure aided drug design
Class: hydrolase
Keywords: hydrolase
Deposited on 2014-02-26, released 2015-02-11
The last revision prior to the SCOPe 2.08 freeze date was dated 2015-02-11, with a file datestamp of 2015-02-06.
Experiment type: XRAY
Resolution: 1.25 Å
R-factor: 0.1764
AEROSPACI score: 0.7 (click here for full SPACI score report)

Chains and heterogens:

  • Chain 'A':
    Compound: Coagulation factor XI
    Species: Homo sapiens [TaxId:9606]
    Database cross-references and differences (RAF-indexed):
    • Uniprot P03951 (0-End)
      • engineered mutation (64)
      • engineered mutation (67)
      • engineered mutation (105)
      • engineered mutation (112)
    Domains in SCOPe 2.08: d4crga_
  • Heterogens: GOL, J4X, SO4, HOH

PDB Chain Sequences:

  • Chain 'A':
    Sequence, based on SEQRES records: (download) 
    >4crgA (A:)
ivggtasvrgewpwqvtlhttsptqrhlcggsiignqwiltaahcfygvespkilrvysg
ilnqaeiaedtsffgvqeiiihdqykmaesgydiallklettvnyadsqrpislpskgdr
nviytdcwvtgwgyrklrdkiqntlqkakiplvtneecqkryrghkithkmicagyregg
kdackgdsggplsckhnevwhlvgitswgegcaqrerpgvytnvveyvdwilektqav

    Sequence, based on observed residues (ATOM records): (download) 
    >4crgA (A:)
ivggtasvrgewpwqvtlhttsptqrhlcggsiignqwiltaahcfygvespkilrvysg
ilnqaeiaedtsffgvqeiiihdqykmaesgydiallklettvnyadsqrpislpskgdr
ytdcwvtgwgyrklrdkiqntlqkakiplvtneecqkryrghkithkmicagyreggkda
ckgdsggplsckhnevwhlvgitswgegcaqrerpgvytnvveyvdwilektqa