SCOPe 2.08: Structural Classification of Proteins

PDB entry 4cqm

View 4cqm on RCSB PDB site
Description: Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD and NADP
Class: oxidoreductase
Keywords: oxidoreductase, kar, ketoacyl reductase, 3-ketoacyl-acp reductase, ke6, hsd8, 17-beta hydroxysteroid dehydrogenase, hsd17b8, 3r-hydroxyacyl-coa dehydrogenase, cbr4, carbobyl reductase type4, nad, nadh, nadp, nadph, hetero tetramer,
Deposited on 2014-02-19, released 2014-09-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-09-17, with a file datestamp of 2014-09-12.
Experiment type: XRAY
Resolution: 2.34 Å
R-factor: 0.2049
AEROSPACI score: 0.28 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqma_
Chain 'B':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
  - expression tag (3-6)
Domains in SCOPe 2.08: d4cqmb1, d4cqmb2
Chain 'C':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (Start-243)
Domains in SCOPe 2.08: d4cqmc_
Chain 'D':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqmd_
Chain 'E':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqme_
Chain 'F':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
  - expression tag (3-6)
Domains in SCOPe 2.08: d4cqmf1, d4cqmf2
Chain 'G':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (Start-243)
Domains in SCOPe 2.08: d4cqmg_
Chain 'H':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqmh_
Chain 'I':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqmi_
Chain 'J':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
  - expression tag (4-6)
Domains in SCOPe 2.08: d4cqmj1, d4cqmj2
Chain 'K':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
Domains in SCOPe 2.08: d4cqmk_
Chain 'L':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqml_
Chain 'M':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqmm_
Chain 'N':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
  - expression tag (4-6)
Domains in SCOPe 2.08: d4cqmn1, d4cqmn2
Chain 'O':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
Domains in SCOPe 2.08: d4cqmo_
Chain 'P':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqmp_
Heterogens: NAP, GOL, EDO, ACT, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>4cqmA (A:)
masqlqnrlrsalalvtgagsgigravsvrlagegatvaacdldraaaqetvrllggpgs
kegpprgnhaafqadvsearaarclleqvqacfsrppsvvvscagitqdefllhmseddw
dkviavnlkgtflvtqaaaqalvsngcrgsiinissivgkvgnvgqtnyaaskagviglt
qtaarelgrhgircnsvlpgfiatpmtqkvpqkvvdkitemipmghlgdpedvadvvafl
asedsgyitgtsvevtgglfm