SCOPe 2.08: Structural Classification of Proteins

PDB entry 4cql

View 4cql on RCSB PDB site
Description: Crystal structure of heterotetrameric human ketoacyl reductase complexed with NAD
Class: oxidoreductase
Keywords: oxidoreductase, kar, 3-ketoacyl-acp reductase, hsd8, 17-beta hydroxysteroid dehydrogenase, hsd17b8, 3r- hydroxyacyl-coa dehydrogenase, carbobyl reductase type4, nadh, nadp, nadph, hetero tetramer,
Deposited on 2014-02-19, released 2014-09-10
The last revision prior to the SCOPe 2.08 freeze date was dated 2014-09-17, with a file datestamp of 2014-09-12.
Experiment type: XRAY
Resolution: 2.85 Å
R-factor: 0.185
AEROSPACI score: 0.22 (click here for full SPACI score report)

Chains and heterogens:

Chain 'A':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqla_
Chain 'B':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
  - expression tag (5-6)
Domains in SCOPe 2.08: d4cqlb1, d4cqlb2
Chain 'C':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (Start-243)
Domains in SCOPe 2.08: d4cqlc_
Chain 'D':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506
Domains in SCOPe 2.08: d4cqld_
Chain 'E':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqle_
Chain 'F':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
  - expression tag (2-6)
Domains in SCOPe 2.08: d4cqlf1, d4cqlf2
Chain 'G':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (Start-243)
Domains in SCOPe 2.08: d4cqlg_
Chain 'H':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqlh_
Chain 'I':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqli_
Chain 'J':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
  - expression tag (5-6)
Domains in SCOPe 2.08: d4cqlj1, d4cqlj2
Chain 'K':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (Start-243)
Domains in SCOPe 2.08: d4cqlk_
Chain 'L':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqll_
Chain 'M':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqlm_
Chain 'N':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
  - expression tag (3-6)
Domains in SCOPe 2.08: d4cqln1, d4cqln2
Chain 'O':
Compound: carbonyl reductase family member 4
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q8N4T8 (7-243)
Domains in SCOPe 2.08: d4cqlo_
Chain 'P':
Compound: Estradiol 17-beta-dehydrogenase 8
Species: Homo sapiens [TaxId:9606]
Database cross-references and differences (RAF-indexed):
- Uniprot Q92506 (Start-260)
Domains in SCOPe 2.08: d4cqlp_
Heterogens: NAD, HOH

PDB Chain Sequences:

Chain 'A':
Sequence, based on SEQRES records: (download)

>4cqlA (A:)
masqlqnrlrsalalvtgagsgigravsvrlagegatvaacdldraaaqetvrllggpgs
kegpprgnhaafqadvsearaarclleqvqacfsrppsvvvscagitqdefllhmseddw
dkviavnlkgtflvtqaaaqalvsngcrgsiinissivgkvgnvgqtnyaaskagviglt
qtaarelgrhgircnsvlpgfiatpmtqkvpqkvvdkitemipmghlgdpedvadvvafl
asedsgyitgtsvevtgglfm